<http://linked.opendata.cz/resource/domain/vavai/cep/projekt/MSM/VS96149>	<http://purl.org/dc/terms/title>	"Strategy of oral immunization: significance for systemic and mucosal immunity and use for prevention and therapy"@en .
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<http://linked.opendata.cz/resource/domain/vavai/cep/projekt/MSM/VS96149>	<http://linked.opendata.cz/ontology/domain/vavai/id-aktivity>	<http://linked.opendata.cz/resource/domain/vavai/cep/aktivita/VS> .
<http://linked.opendata.cz/resource/domain/vavai/cep/projekt/MSM/VS96149>	<http://linked.opendata.cz/ontology/domain/vavai/uznane-naklady>	"51532"^^<http://www.w3.org/2001/XMLSchema#integer> .
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<http://linked.opendata.cz/resource/domain/vavai/cep/projekt/MSM/VS96149>	<http://linked.opendata.cz/ontology/domain/vavai/vedlejsi-obor>	<http://linked.opendata.cz/resource/domain/vavai/cep/obor/EE> .
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<http://linked.opendata.cz/resource/domain/vavai/cep/projekt/MSM/VS96149>	<http://purl.org/dc/terms/description>	"Budou sledov\u00E1ny mo\u017Enosti ovlivn\u011Bn\u00ED syst\u00E9mov\u00E9 a slizni\u010Dn\u00ED imunity po or\u00E1ln\u00ED imunizaci. Bude testov\u00E1n \u00FA\u010Dinek r\u016Fzn\u00FDch adjuvanci\u00ED, nosi\u010D\u016F a vektor\u016F: Bacillus firmus jako adjuvans a nosi\u010D (ervent. vektor), mutanta Escherichia coli 083 K24 H31 hlyA- jako \u017Eiv\u00FD vektor, adenyl\u00E1t-cykl\u00E1zov\u00FD \u00E9 mechanismy uplat\u0148uj\u00EDc\u00ED se p\u0159i patogeneze celiakie. V\u00FDsledky mohou b\u00FDt vyu\u017Eiteln\u00E9 pro rozvoj nov\u00FDch vakcina\u010Dn\u00EDch strategi\u00ED."@cs .
<http://linked.opendata.cz/resource/domain/vavai/cep/projekt/MSM/VS96149>	<http://purl.org/dc/terms/description>	"Possibilities of modulation of mucosal and systemic immunity after oral immunization will be studied. The effect of various adjuvants, carriers and vectors on induction of protective immunity or oral tolerance will be tested. Bacillus firmus has strong immunomodulatory activities and will be used as adjuvant and antigen carrier. A mutant of E. coli O83 K24 H31 hlyA- with excellent intestine colonizing properties will be used as live vector for tetanic toxin. Effectiveness of adenylate-cyclase toxin (ACT) of Bordetella pertussis as a constituent of subunit vaccine against pertussis will be followed. Integration of various heterologous epitopes into ACT can influence their presentation to lymphocytes and character of immune response. Chimeric ACT with gliadin epitopes will be exploited in the study of antigen presentation and its significance for pathogeny of celiac disease. The results expected could be used"@en .
<http://linked.opendata.cz/resource/domain/vavai/cep/projekt/MSM/VS96149>	<http://linked.opendata.cz/ontology/domain/vavai/pocet-vysledku>	"23"^^<http://www.w3.org/2001/XMLSchema#integer> .
<http://linked.opendata.cz/resource/domain/vavai/cep/projekt/MSM/VS96149>	<http://purl.org/dc/terms/title>	"Strategie or\u00E1ln\u00ED imunizace, jej\u00ED v\u00FDzkum pro syst\u00E9movou a slizni\u010Dn\u00ED imunitu a vyu\u017Eit\u00ED k preventivn\u00EDm a l\u00E9\u010Debn\u00FDm \u00FA\u010Del\u016Fm"@cs .
<http://linked.opendata.cz/resource/domain/vavai/cep/projekt/MSM/VS96149>	<http://linked.opendata.cz/ontology/domain/vavai/klicova-slova>	"mucosal immunity; peroral immunization; oral tolerance; mucosal adjuvants; antigen carriers; mucosal"@en .
<http://linked.opendata.cz/resource/domain/vavai/cep/projekt/MSM/VS96149>	<http://linked.opendata.cz/ontology/domain/vavai/druh-souteze>	<http://linked.opendata.cz/resource/domain/vavai/cep/druh-souteze/> .
<http://linked.opendata.cz/resource/domain/vavai/cep/projekt/MSM/VS96149>	<http://linked.opendata.cz/ontology/domain/vavai/hlavni-obor>	<http://linked.opendata.cz/resource/domain/vavai/cep/obor/EA> .
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<http://linked.opendata.cz/resource/domain/vavai/cep/projekt/MSM/VS96149>	<http://linked.opendata.cz/ontology/domain/vavai/id-souteze>	<http://linked.opendata.cz/resource/domain/vavai/cep/soutez/> .
<http://linked.opendata.cz/resource/domain/vavai/cep/projekt/MSM/VS96149>	<http://linked.opendata.cz/ontology/domain/vavai/dalsi-vedlejsi-obor>	<http://linked.opendata.cz/resource/domain/vavai/cep/obor/FO> .
<http://linked.opendata.cz/resource/domain/vavai/cep/projekt/MSM/VS96149>	<http://linked.opendata.cz/ontology/domain/vavai/faze>	<http://linked.opendata.cz/resource/domain/vavai/cep/faze/20063898> .
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