"13000"^^ . "V p\u0159edkl\u00E1dan\u00E9m projektu budou \u0159e\u0161eny ot\u00E1zky vztah\u016F mezi strukturou a vlastnostmi polysacharid\u016F mucinov\u00E9ho typu a jejich syntetick\u00FDch deriv\u00E1t\u016F. Budou p\u0159ipraveny antigeny T, Tn a sTn a jejich strukturn\u00ED modifikace. D\u00E1le budou studov\u00E1ny mechanismy reakc\u00ED peptid\u016F a aminokyselin s Pt(II) a Pd(II). Budou p\u0159ipraveny komplexy lanthanoid\u016F s makrocyklick\u00FDmi ligandy a studov\u00E1na mo\u017Enost vyu\u017Eit\u00ED t\u011Bchto komplex\u016F jako posuvov\u00FDch \u010Dinidel v NMR."@cs . "Preparation and study of biologically active biopolymers and selected model-compounds"@en . "21"^^ . . "21"^^ . . . "0"^^ . "NMR spectroscopy, Tn antigens, glycopeptides, mucine-type polysacharydes, macrocycles,"@en . "73525"^^ . "1"^^ . . "\"One of the most rapidly advancing area of the biomedicinal research deals with study of relationship between chemical structure and biological activity. This research is currently facilitated by methods of modern structural analysis , mainly NMR and MS .In the framework of this project, we intend to pay an attention to following problems: I. Study of th mucine-type polysaccharides and their synthetic derivatives. Antigens of T, Tn and sTn will be synthesized on the polymeric resin. II. Study of mechanisms of Pt(II) and Pd(II) reactions with aminoacids and oligopeptides which is related to mechasism of action of \"\"cisplatinum\"\" III. Preparation and study of complexes of lanthanoides with macrocyclic ligands These comlexes may act as a shift reagents in the NMR spectroscopy or can be used in the study of biological materials.\""@en . . . . . . "0"^^ . . "P\u0159\u00EDprava a studium biologicky aktivn\u00EDch biopolymer\u016F a vybran\u00FDch modelov\u00FDch l\u00E1tek"@cs . .