. . . . . . . "gene expression, nucleus, splicing, transcription, benzodiazepine dependence, GABA-A receptor, autoa"@en . "0"^^ . "Gene expression with a special emphasis on a structure-functional organization of transcription and splicing apparatus."@en . "R\u016Fst, diferenciace a v\u00FDvoj organismu je v\u00FDrazem koordinovan\u00E9 exprese \u0161irok\u00E9 \u0159ady gen\u016F. Indukce transkripce, synt\u00E9za RNA a jej\u00ED vyzr\u00E1v\u00E1n\u00ED p\u0159edstavuj\u00ED slo\u017Eit\u00E9 komplexy nitrojadern\u00FDch jev\u016F, v jejich\u017E regulaci hraj\u00ED kl\u00ED\u010Dovou roli proteinov\u00E9 a nukleoproteinov\u00E9 faktory p\u016Fsob\u00EDc\u00ED na r\u016Fzn\u00FDch \u00FArovn\u00EDch. V projektu se pokus\u00EDme o spln\u011Bn\u00ED n\u011Bkolika metodicky navz\u00E1jem prov\u00E1zan\u00FDch c\u00EDl\u016F z hlediska genov\u00E9 exprese v oblasti molekul\u00E1rn\u00ED bun\u011B\u010Dn\u00E9 biologie (strukturn\u011B funk\u010Dn\u00ED integrace transkrip\u010Dn\u00EDho a sest\u0159ihov\u00E9ho apar\u00E1tu do bun\u011B\u010Dk\u00E9 architektury), molekul\u00E1rn\u00ED patologie (exprese protoonkogenu bcl-1), molekul\u00E1rn\u00ED imunologie (exprese adhesivn\u00EDch molekult b\u011Bhem z\u00E1n\u011Btliv\u00E9 reakce, exprese imunoglobulinov\u00FDch gen\u016F u syst\u00E9mov\u00E9ho revmatick\u00E9ho onemocn\u011Bn\u00ED) a molekul\u00E1rn\u00ED farmakologie (modulace exprese protoonkogenu bcl-1), molekul\u00E1rn\u00ED imunologie (exprese adhesivn\u00EDch molekult b\u011Bhem z\u00E1n\u011Btliv\u00E9 reakce, exprese imunoglobulinov\u00FDch gen\u016F u syst\u00E9mov\u00E9ho revmatick\u00E9ho onemocn\u011Bn\u00ED) a molekul\u00E1rn\u00ED farmakologie (modulace exprese GABA receptoru benzodiaz"@cs . "Laborato\u0159 genov\u00E9 exprese"@cs . "Laboratory of gene expression"@en . . "1"^^ . . "28732"^^ . "35"^^ . "0"^^ . "115400"^^ . . "35"^^ . .