. "Prodrug; antimycobacterial activity; MDR strains of tuberculosis"@en . . "Our investigation is based on molecular modelling of new anti-tuberculosis drugs and prodrugs, their synthesis, antimycobacterial activity evaluation in vitro and searching for new mechanisms of activity. The aim of the research is the cooperation in the synthesis of new antibacterial active compounds possessing select criteria (activity, minor multi drug resistance, minimum of side effects, high index selectivity) that would make them suitable for preclinical evaluation."@en . . "2010-01-01+01:00"^^ . . "0"^^ . "V\u00FDvoj nov\u00FDch perspektivn\u00EDch antituberkulotik a jejich prol\u00E9\u010Div aktivn\u00EDch v\u016F\u010Di multirezistentn\u00EDm kmen\u016Fm"@cs . . "0"^^ . . "0"^^ . "Development of Novel Antituberculosis Agents and Prodrugs Effective against Multidrug Resistant Tuberculosis"@en . "0"^^ . "1"^^ . . "2011-12-31+01:00"^^ . "112"^^ . "C\u00EDlem projektu je modelov\u00E1n\u00ED, synt\u00E9za a biologick\u00E9 hodnocen\u00ED in vitro nov\u00FDch antituberkuloticky aktivn\u00EDch l\u00E9\u010Div a jejich prodrug forem, hled\u00E1n\u00ED nov\u00FDch mechanism\u016F \u00FA\u010Dinku, aby spl\u0148ovaly po\u017Eadovan\u00E1 kriteria (aktivitu, minim\u00E1ln\u00ED multil\u00E9kovou rezistenci, co nejm\u00E9n\u011B vedlej\u0161\u00EDch \u00FA\u010Dink\u016F a vysok\u00FD index selektivity)."@cs . . "112"^^ . . . . .