"0"^^ . "2868"^^ . "The main objective is to increase knowledge and understanding of the mechanisms of action of antitumour metallodrugs, and to use this enhanced knowledge in combination with modern genomic research to develop new classes of metallodrugs with truly novel mechanisms of action and novel spectra of biomedical activity."@en . "2010-05-01+01:00"^^ . "1"^^ . . "0"^^ . "Transition metal-based anticancer compounds. From mechanistic studies to innovatory cancer chemotherapy"@en . . . "2868"^^ . . . "Cancer; chemotherapy; antitumor drugs; DNA; platinum; ruthenium; antitumor activity"@en . "Protin\u00E1dorov\u011B \u00FA\u010Dinn\u00E9 slou\u010Deniny p\u0159echodn\u00FDch kov\u016F. Od mechanistick\u00FDch studi\u00ED k inovac\u00EDm v chemoterapii rakoviny"@cs . . "2012-12-31+01:00"^^ . . "9"^^ . . . "9"^^ . . . . "C\u00EDlem tohoto v\u00FDzkumu je zjistit \u00FAdaje o molekul\u00E1rn\u00EDch mechanismech protin\u00E1dorov\u00E9ho p\u016Fsoben\u00ED metalofarmak odvozen\u00FDch od p\u0159echodn\u00FDch kov\u016F. Nov\u00E9 znalosti z\u00EDskan\u00E9 p\u0159i \u0159e\u0161en\u00ED tohoto projektu vyu\u017E\u00EDt pro n\u00E1vrhy nov\u00FDch typ\u016F cytostatik"@cs .