. "1947"^^ . "0"^^ . "2010-05-01+01:00"^^ . "1"^^ . . "0"^^ . "Development of novel activity assay for GCPII/GCPIII based on fluorescence anisotropy that, in turn, will be exploited for the identification of novel inhibitor scaffolds targeting GCPII/GCPIII. Identification of novel GCPII/GCPIII inhibitors using in silico and in vitro testing. Structure-based modifications of novel as well as existing GCPII/GCPIII inhibitors to simplify synthesis, improve their pharmacokinetic properties and/or increase liphophilicity and/or affinity. Biochemical and physiological characterization of optimized and newly identified GCPII/GCPIII inhibitors."@en . "3"^^ . "V\u00FDvoj nov\u00E9ho aktivitn\u00EDho stanoven\u00ED vyu\u017Eiteln\u00E9ho k identifikaci a optimalizaci inhibitor\u016F GCPII a GCPIII. Optimalizace inhibitor\u016F uveden\u00FDch enzym\u016F s vyu\u017Eit\u00EDm rentgenostrukturn\u00ED anal\u00FDzy."@cs . . . . "3"^^ . "2012-12-31+01:00"^^ . "Structure-based design of ligands and inhibitors targeting glutamate carboxypeptidase II and its homologs"@en . . "Racion\u00E1ln\u00ED n\u00E1vrh ligand\u016F a inhibitor\u016F glutam\u00E1t karboxypeptidasy II a jej\u00EDch homolog\u016F"@cs . . . "glutamate carboxypeptidase II prostate-specific membrane antigen X-ray crystallography structure-based drug design"@en . "1947"^^ . . . .