. "2007-04-01+01:00"^^ . "90"^^ . . "1"^^ . "3"^^ . "Centrum funk\u010Dn\u00ED genetiky"@cs . . "90"^^ . "0"^^ . "Functional genetics; transfection; reverse genetics; protists; invertebrates; insects"@en . . . "Center for Functional Genetics"@en . "60711"^^ . . . . "60211"^^ . "2011-12-31+01:00"^^ . "Identifikace nov\u00FDch funkc\u00ED gen\u016F a jejich produkt\u016F vytipovan\u00FDch na z\u00E1klad\u011B anal\u00FDzy genom\u016F modelov\u00FDch organism\u016F s terapeutick\u00FDm a biotechnologick\u00FDm potenci\u00E1lem."@cs . . . "The project is focused on functional studies of genes and their products with therapeutic and biotechnological potential using novel model organisms. The organisms include those with negative impact on quality of human life such as direct human and animal pathogens and vectors of infectious agents. In the first phase, advanced methods of molecular genetics will be established and/or optimalized in these organisms. In the second phase, the genes of interest will be selected on the basis of genomic, proteomic, and transcriptomic analyses with particular interest in genes associated with development of human diseases. The gene selection will be focused on factors of pathogenicity, oncoproteins, components of FeS assembly machinery including frataxin, nuclear receptors, circadian clock genes, developmental genes, etc. The function of selected genes will then be tested using the newly established systems as well as with the aid of the classical yeast model."@en . .