"*When diagnosing pheochromocytoma, the most commonly u\u0161ed laboratory analysis method for catecholamines and their metabolites, especially metanephrine and normetanephrine, in urine and plasma, is HPLC. This method is usu-ally developed and validated by individual laboratories as there is no affordable plasma free metanephrine analysis kit manufactured in the EU. This project is a concept fordevelopment of a new plasma free metanephrine HPLC analysis kit. Certified method of analysis will respect interfering effects of pharmaceuticals and their metabolites in plasma and variability of matrix effects."@en . "*The development of a plasma free metanephrine analysis kit"@en . . "*P\u0159i diagnostikov\u00E1n\u00ED feochromocytomu se pou\u017E\u00EDv\u00E1 laboratorn\u00ED metoda stanoven\u00ED katecholamin\u016F a jejich metabolit\u016F, zejm\u00E9na metanefrinu a normetanefrinu v mo\u010Di a v plazm\u011B, nejb\u011B\u017En\u011Bji metoda HPLC, kterou si jednotliv\u00E9 laborato\u0159e sami vyv\u00EDjej\u00ED a validuj\u00ED, jeliko\u017E v EU cenov\u011B dostupn\u00FD kit pro stanoven\u00ED plazmatick\u00FDch metanefrinu nikdo nevyr\u00E1b\u00ED. Projekt je n\u00E1vrhem v\u00FDvoje nov\u00E9ho kitu pro HPLC stanoven\u00ED plazmatick\u00FDch metanefrin\u016F. Certifikovan\u00E1 metoda stanoven\u00ED bude respektovat interferuj\u00EDc\u00ED efekty l\u00E9\u010Div a jejich metabolit\u016F v plazm\u011B a variabilitu matri\u010Dn\u00EDch efekt\u016F."@cs . . . . . . . . . "2012-01-01+01:00"^^ . . . "kit; metanephrines; plasma; plasma metanephrines; katecholamines"@en . "0"^^ . "0"^^ . "7765"^^ . . "12000"^^ . "2014-12-31+01:00"^^ . "*V\u00FDvoj kitu pro stanoven\u00ED plazmatick\u00FDch metanefrin\u016F"@cs . "2"^^ . "0"^^ . "1"^^ .