. "14812"^^ . . "0"^^ . . . "2010-07-01+01:00"^^ . . . "*V\u00FDvoj kitu na testov\u00E1n\u00ED \u00FA\u010Dinosti protin\u00E1dorov\u00E9 l\u00E9\u010Dby ovliv\u0148uj\u00EDc\u00ED strukturu jadern\u00E9ho chromatinu"@cs . . "*Development of kit for testing molecular effects of anti-tumor drugs on chromatin structure"@en . "2014-06-30+01:00"^^ . "kit development; quantitative chromatin immunoprecipitation; histone modification; histone acetyltransferases"@en . . "*Malignances represent important socio-economic problem caused at molecular levels by uncontrolled cell proliferation and block of cell differentiation. Biological anti-tumor therapy is aimed to interfere with mechanisms that are behind these molecular defects and targeting the chromatin structure represents one of the promising therapeutic strategies. The proposed aim of this project is to develop a kit to detect chromatin changes closed to key hematopoietic genes to optimize and rationalize therapy using HDACi (histone deacetylase inhibitors) in human leukemia."@en . "1"^^ . "35"^^ . . "1"^^ . "19350"^^ . . "*N\u00E1dorov\u00E1 onemocn\u011Bn\u00ED jsou z\u00E1va\u017En\u00E1 onemocn\u011Bn\u00ED zp\u016Fsoben\u00E1 nekontrolovan\u00FDm d\u011Blen\u00EDm bun\u011Bk, neschopn\u00FDch dokon\u010Dit sv\u016Fj p\u0159irozen\u00FD v\u00FDvoj. Biologick\u00E1 protin\u00E1dorov\u00E1 l\u00E9\u010Dba je zam\u011B\u0159ena na ovlivn\u011Bn\u00ED p\u0159\u00ED\u010Din n\u00E1dorov\u00E9ho bujen\u00ED, kdy jedn\u00EDm z nov\u00FDch biologick\u00FDch protin\u00E1dorov\u00FDch p\u0159\u00EDstup\u016F je ovlivn\u011Bn\u00ED funkce na \u00FArovni jadern\u00E9ho chromatinu. Metoda detekce jadern\u00E9 chromatinov\u00E9 struktury reflektuj\u00EDc\u00ED stav p\u0159ed a po l\u00E9\u010Db\u011B chromatin-modula\u010Dn\u00EDmi l\u00E9ky je hlavn\u00EDm c\u00EDlem navrhovan\u00E9ho projektu. C\u00EDlem projektu je sestavit kit pro detekci chromatinov\u00FDch zm\u011Bn regula\u010Dn\u00EDch sekvenc\u00ED krvetvorn\u00FDch transkrip\u010Dn\u00EDch faktor\u016F pomoc\u00ED chromatinov\u00E9 imunoprecipitace na \u00FArovn\u00ED histonov\u00FDch zm\u011Bn u leukemick\u00FDch bun\u011Bk po p\u0159id\u00E1n\u00ED l\u00E1tek ovliv\u0148uj\u00EDc\u00EDch acetylaci chromatinu (HDACi). Tento postup nahrad\u00ED sou\u010Dasnou praxi opom\u00EDjen\u00ED t\u011Bchto specifick\u00FDch metod a p\u0159inese specifickou anal\u00FDzu s minim\u00E1ln\u00ED trv\u00E1n\u00EDm, je\u017E povede k \u00FAspo\u0159e prost\u0159edk\u016F p\u0159i racionalizaci terapie."@cs . . "35"^^ . .