. . "2006-03-01+01:00"^^ . "1"^^ . . "7462"^^ . "INTOX - Nov\u00FD zp\u016Fsob profylaxe, dekontaminace, diagnostiky a terapie p\u0159i intoxikaci NPL a yperity"@cs . "Intoxication; prophylaxis; decontamination; diagnostics; therapy; intoxication; nerve agents; yperits"@en . . "34"^^ . "2008-12-31+01:00"^^ . "Development of our knowledge about the prophylactic efficacy of cholinesterase preparation against nerve agent intoxication by means of toxicological methods and the decision about directions of new approach to prophylaxis to achieve better prophylactic effect in low doses at inhalation exposure. Verification of decontamination effect based on reverse micellar systems against chemical warfare agents in vivo and decision on further research direction. Evaluation of efficacy of potential AChE reactivators and to find the reactivator able to reactivate nerve agent-inhibited AChE regardless of the type of nerve agent. The validation of the method estimating of DNA cross-links induced by sulphur mustard in cells incubated in vitro. By means of this method, to test a possible influence of selected antimutagens/combinations on the effect of sulphur mustard. The antimutagenic effect will be also verified by the observation of the induction of chromosomal damage in bone marrow cells of mice."@en . "0"^^ . . "34"^^ . "8842"^^ . "Roz\u0161\u00ED\u0159en\u00ED na\u0161ich znalost\u00ED o profylaktick\u00E9m p\u016Fsoben\u00ED prepar\u00E1t\u016F cholinester\u00E1zy proti intoxikaci NPL pomoc\u00ED toxikologick\u00FDch metod a rozhodnout o sm\u011Brech k profylaxi k lep\u0161\u00EDmu profylaktick\u00E9mu \u00FA\u010Dinku pro ochranu proti otrav\u011B NPL v n\u00EDzk\u00FDch d\u00E1vk\u00E1ch p\u0159i inhalaci. Ov\u011B\u0159en\u00ED nov\u00E9ho zp\u016Fsobu odmo\u0159ov\u00E1n\u00ED na b\u00E1zi reversn\u00EDch micel, otestov\u00E1n\u00ED \u00FA\u010Dinnosti proti r\u016Fzn\u00FDm typ\u016Fm OL in vivo. a rozhodnout o dal\u0161\u00EDm sm\u011Bru v\u00FDzkumu. S vyu\u017Eit\u00EDm t\u011Bchto metod prov\u011B\u0159it \u00FA\u010Dinnost potenci\u00E1ln\u00EDch reaktiv\u00E1tor\u016F AChE s c\u00EDlem nal\u00E9zt reaktiv\u00E1tor \u00FA\u010Dinn\u00FD na AChE inhibovanou NPL bez ohledu na typ. Vypracov\u00E1n\u00ED a ov\u011B\u0159en\u00ED metody stanoven\u00ED k\u0159\u00ED\u017Eov\u00FDch vazeb v DNA indukovan\u00FDch sirn\u00FDm yperitem u bun\u011Bk in vitro a otestovt vliv n\u011Bkter\u00FDch antimutagen\u016F /kombinac\u00ED na \u00FA\u010Dinek yperitu. Antimutagenn\u00ED \u00FA\u010Dinky ov\u011B\u0159it in vivo sledov\u00E1n\u00EDm frekvence po\u0161kozen\u00ED chromozom\u016F bun\u011Bk kostn\u00ED d\u0159en\u011B my\u0161\u00ED."@cs . . . . . . . "0"^^ . "A new method of prophylaxis, decontamination, diagnostics and therapy afer intoxication with nerve agents and yperits"@en .