. . "3"^^ . "Tento projekt komplexn\u00EDho v\u00FDzkumu interakc\u00ED biomakromolekul s elektricky nabit\u00FDmi povrchy je zalo\u017Een na ned\u00E1vn\u00E9m pokroku dosa\u017Een\u00E9m v laborato\u0159\u00EDch navrhovatel\u016F (viz text) p\u0159i rozvoji elektrochemick\u00FDch technik a p\u0159i studi\u00EDch interakc\u00ED nukleov\u00FDch kyselin a b\u00EDlkovin se rtu\u0165ovou elektrodou a pevn\u00FDmi elektrodami. V tomto projektu budou z\u00EDsk\u00E1ny z\u00E1kladn\u00ED informace o adsorpci a desorpci, redoxn\u00EDch a strukturn\u00EDch vlastnostech DNA, RNA, oligonukleotid\u016F, b\u00EDlkovin a mal\u00FDch peptid\u016F na mezif\u00E1z\u00ED. V\u00FDsledkem t\u011Bchto studibude v\u00FDvoj elektrochemick\u00FDch vysoce citliv\u00FDch metod, zahrnuj\u00EDc\u00EDch (a) rychle reaguj\u00EDc\u00ED senzory po\u0161kozen\u00ED DNA, (b) rychle reaguj\u00EDc\u00ED senzory hybridizace DNA, (c) nov\u00E9 metody pro studium interakc\u00ED DNA se specifick\u00FDmi b\u00EDlkovinami a protin\u00E1dorov\u011B \u00FA\u010Dinn\u00FDmi l\u00E9\u010Divy, apod. Rovn\u011B\u017E bude z\u00EDsk\u00E1na informace o lok\u00E1ln\u00EDch struktur\u00E1ch DNA p\u0159i neurologick\u00FDch genetick\u00FDch onemocn\u011Bn\u00EDch a o interakc\u00EDch DNA s b\u00EDlkovinou p53 u lidsk\u00E9 rakoviny. Hlavn\u00EDm c\u00EDlem je v\u00FDvoj elektrod modifikovan\u00FDch nukleov\u00FDmi kyselinami a b\u00EDlkovinami"@cs . . "0"^^ . "166"^^ . "19597"^^ . "166"^^ . "This project of complex studies of biomacromolecule interactions with electrically charged surfaces is based on the recent progress reached in the proposers' laboratories (see the text) in the development of the electrochemical techniques and in the studies of interactions of nucleic acids and proteins with the mercury electrode and solid surfaces. In this project basic information about the adsorption/desorption, redox properties and structural features of DNA, RNA, oligonucleotides, proteins and small peptides at interfaces will be obtained. As a result of these studies electrochemical ultramicromethods will be developed including (a) fast response sensors of the DNA damage (b) fast response sensors of the DNA hybridization c new methods for studies of the interaction of DNA with specific proteins and anticancer drugs, etc. In addition information about the DNA local structures in neurological genetic diseases and about the DNA-p53 protein interactions in human cancer will be obtained. The m"@en . "1"^^ . . . "Electrodes modified with nucleic acids and proteins.New tools in biochemical and biomedical research."@en . . . . "Elektrody modifikovan\u00E9 nukleov\u00FDmi kyselinami a b\u00EDlkovinami. Nov\u00E9 n\u00E1stroje v biochemick\u00E9m a biomedic\u00EDnsk\u00E9m v\u00FDzkumu"@cs . . "Neuvedeno."@en . . . "40410"^^ .