"1"^^ . . "0"^^ . "biomaterial; nanoparticle; amphilic block copolymer; biomimetic surface"@en . "1008"^^ . . "Preparation of surface nanoclusters of integrin ligands for control of cell adhesion"@en . "Surfaces that mimic signaling properties of the extracellular matrix in vivo through the presentation of ligands of integrins (cell membrane receptors) can significantly contribute to the functionality of many biomedical systems including\u00A0 cell delivery scaffolds for tissue engineering. The main objective of the project is to develop a novel method for preparation of cell adhesive surfaces containing nanoclusters of peptide-derived integrin ligands using spherical nanoparticles assembled from amphiphilic diblock copolymers. Ligands will be conjugated on the nanoparticles to create nanoscale clusters that will be consecutively immobilized to model surfaces. As compared to commonly studied synthetic biomimetic surfaces with randomly distributed ligands, the method to be developed will provide a significant improvement in the control of cell adhesion and related cellular activities such as migration, proliferation and differentiation."@en . . . "2012-12-31+01:00"^^ . . "1"^^ . . . "2010-01-01+01:00"^^ . . . . "1"^^ . "P\u0159\u00EDprava povrchov\u00FDch nanoklastr\u016F integrinov\u00FDch ligand\u016F pro \u0159\u00EDzen\u00ED bun\u011B\u010Dn\u00E9 adheze"@cs . "1008"^^ . "0"^^ . "Povrchy, kter\u00E9 napodobuj\u00ED sign\u00E1ln\u00ED vlastnosti mimobun\u011B\u010Dn\u00E9 hmoty in vivo exponov\u00E1n\u00EDm ligand\u016F integrin\u016F (bun\u011B\u010Dn\u00FDch receptor\u016F), mohou v\u00FDznamn\u00FDm zp\u016Fsobem p\u0159isp\u011Bt k funk\u010Dnosti \u0159ady biol\u00E9ka\u0159sk\u00FDch syst\u00E9m\u016F v\u010Detn\u011B nosi\u010D\u016F bun\u011Bk pro tk\u00E1\u0148ov\u00E9 in\u017Een\u00FDrstv\u00ED. C\u00EDlem tohoto projektu je vyvinout novou metodu pro p\u0159\u00EDpravu povrch\u016F s nanoklastry peptidick\u00FDch integrinov\u00FDch ligand\u016F s vyu\u017Eit\u00EDm sf\u00E9rick\u00FDch nano\u010D\u00E1stic sestaven\u00FDch z amfifiln\u00EDch dvoublokov\u00FDch kopolymer\u016F. Nav\u00E1z\u00E1n\u00EDm peptidick\u00FDch ligand\u016F na nano\u010D\u00E1stice budou vytvo\u0159eny klastry, kter\u00E9 budou n\u00E1sledn\u011B imobilizov\u00E1ny na modelov\u00E9 povrchy. Ve srovn\u00E1n\u00ED s b\u011B\u017En\u011B studovan\u00FDmi biomimetick\u00FDmi povrchy s n\u00E1hodn\u011B rozm\u00EDst\u011Bn\u00FDmi ligandy, tato nov\u00E1 metoda poskytne v\u011Bt\u0161\u00ED potenci\u00E1l pro \u0159\u00EDzen\u00ED bun\u011B\u010Dn\u00E9 adheze a s n\u00ED souvisej\u00EDc\u00ED bun\u011B\u010Dn\u00E9 aktivity jako migrace, proliferace a diferenciace."@cs .