"Immunophenotypisation of plasma cells using multiparametric flow cytometry brings enough data to define and distinguish heterogeneous population of neoplastic plasma cells from their normal equivalent. The aim of this project is to identify phenotypic profile in subjects with monoclonal gammopathy. The pathophysiology of plasma cells and changes in their behavior will be studied on cellular and molecular level to detect possible relationship between these changes and possibility of malignant transformation in monoclonal gammopathy of undetermined significance. This project can be used to identify new predictive and prognostic markers. They could lead to definite determination of diagnose, assessment of risk of progression in asymptomatic monoclonal gammopathies with consequent well-timed and accurately targeted treatment. The markers also could help to evaluate minimal residual disease and efficacy of treatment."@en . "Multiparametric flow cytometry in study of malignant plasma cells pathophysiology"@en . . "Uplatn\u011Bn\u00ED multiparametrick\u00E9 pr\u016Ftokov\u00E9 cytometrie ve studiu patofyziologie malign\u00EDch plazmatick\u00FDch bun\u011Bk"@cs . "1200"^^ . . "1"^^ . "monoklon\u00E1ln\u00ED gamapatie; mnoho\u010Detn\u00FD myelom; plazmatick\u00E9 bu\u0148ky; pr\u016Ftokov\u00E1 cytometrie"@en . "0"^^ . . "1200"^^ . . . . . "12"^^ . "2011-12-31+01:00"^^ . "2009-03-01+01:00"^^ . "12"^^ . . . "0"^^ . "Srovn\u00E1n\u00ED fenotypov\u00E9ho profilu norm\u00E1ln\u00EDch a patologick\u00FDch plazmocyt\u016F pomoc\u00ED multi/polychromatick\u00E9 pr\u016Ftokov\u00E9 cytometrie. Charakterizace a selekce plazmocyt\u016F za \u00FA\u010Delem jejich dal\u0161\u00EDch anal\u00FDz. Predikce rizika progrese/relapsu. P\u0159\u00EDnos flowcytometrie pro hodnocen\u00ED minim\u00E1ln\u00ED rezidu\u00E1ln\u00ED choroby."@cs . . . .