"Threedimensional analysis of cell nuclei using image cytometry"@en . "745"^^ . "Neuvedeno."@en . . "Za\u0159\u00EDzen\u00ED naz\u00FDvan\u00E9 obrazov\u00FD cytometr s vysok\u00FDm rozli\u0161en\u00EDm umo\u017E\u0148uje prov\u00E1d\u011Bt detailn\u00ED studie (p\u0159i rozli\u0161en\u00ED srovnateln\u00E9m s konfok\u00E1ln\u00ED mikroskopi\u00ED) na velk\u00E9m mno\u017Estv\u00ED bun\u011B\u010Dn\u00FDch jader obarven\u00FDch metodou FISH (1000-10000 objekt\u016F). Cytometr nach\u00E1z\u00ED uplatn\u011Bn\u00ED jak v z\u00E1kladn\u00EDm biologick\u00E9m v\u00FDzkumu struktury genetick\u00E9ho materi\u00E1lu uvnit\u0159 bun\u011B\u010Dn\u00E9ho j\u00E1dra, tak v klinick\u00FDch aplikac\u00EDch. Jedn\u00E1 se o \u0161pi\u010Dkov\u00FD a sv\u011Btov\u011B jedine\u010Dn\u00FD p\u0159\u00EDstroj, kter\u00FD byl vyvinut v na\u0161\u00ED laborato\u0159i. Jeho omezen\u00EDm v\u0161ak je, \u017Ee nedok\u00E1\u017Ee pln\u011B pracovat ve trojrozm\u011Brn\u00E9m prostoru. Podstatou navrhovan\u00E9ho projektu je roz\u0161\u00ED\u0159it mo\u017Enosti obrazov\u00E9ho cytometru s vysok\u00FDm rozli\u0161en\u00EDm tak, aby na n\u011Bm bylo mo\u017En\u00E9 prov\u00E1d\u011Bt kompletn\u00ED trojrozm\u011Brnou anal\u00FDzu velk\u00E9ho po\u010Dtu bun\u011B\u010Dn\u00FDch jader. Mo\u017Enosti cytometru jsou d\u00E1ny analyza\u010Dn\u00EDm subsyst\u00E9mem, kter\u00FD bude roz\u0161\u00ED\u0159en tak, aby vyhodnocovac\u00ED po\u010D\u00EDta\u010D dok\u00E1zal ve sv\u00E9 opera\u010Dn\u00ED pam\u011Bti vytvo\u0159it trojrozm\u011Brn\u00FD po\u010D\u00EDta\u010Dov\u00FD model bun\u011B\u010Dn\u00E9ho j\u00E1dra. D\u00EDky tomuto modelu bude mo\u017En\u00E9 roz\u0161\u00ED\u0159it sadu m\u011B\u0159en\u00ED, kterou cytometr poskytuje. P\u0159ibude"@cs . "0"^^ . "0"^^ . . "7"^^ . "Trojrozm\u011Brn\u00E1 anal\u00FDza bun\u011B\u010Dn\u00FDch jader s vyu\u017Eit\u00EDm obrazov\u00E9 cytometrie"@cs . "7"^^ . "745"^^ . "An instrument called high-resolution image cytometer provides precise measurements (with resolution comparable to confocal microscopy) on a large number of FISH stained cell nuclei (1000-10000 objects). The cytometer can be used for both basic biologicalresearch (genetic material structure studies) and clinical applications. The cytometer was developed in our laboratory and is unique in the world. This excellent instrument has, unfortunately, one big limitation - it cannot perform full 3D studies. The aim of this project is to improve the high-resolution image cytometer so that it will provide complete 3D analysis of a large number of cell nuclei. Capabilities of image cytometer are determined by the image analysis subsystem, which will be improved. After the extension the computer will be able to construct a 3D model of a cell nucleus in its memory and therefore new set of 3D measurements will be possible, e.g. the computation of point-to-surface distances, volume or area of nuclei or chromozomes."@en . . . . . . . "1"^^ . . . .