"New ligands for recognition of chiral anions"@en . "0"^^ . . . "Nov\u00E9 ligandy pro rozpozn\u00E1n\u00ED chir\u00E1ln\u00EDch aniont\u016F"@cs . "Neuvedeno."@en . . . "1"^^ . "0"^^ . "1"^^ . "1"^^ . "Hydrogen bonding between anion and amide plays important role in the bonding and recognition in natural bonding domains of proteins. There are not known great amount of molecules based on the amides for complexation of anions in the case of artificial receptors. It is possible to activate amide bond by proper method for the interaction with the anions. The influence of substituents on the ability to interact with anions was earlier examined in the our laboratory. It was prepared and examined complexation features of compounds bearing on the both sides of amide bond electronically poor substituents and on the contrary electronically rich substituents. Substituents have influence on the bonding power of anions by the increasing and on the contrary by the decreasing of density of the electrons. How the influence of bonding power affect chiral recognition is not yet known. Similar type of receptors are ureas and thioureas, which can create two hydrogen bonds and therefore they are bonding"@en . "Vod\u00EDkov\u00E1 vazba mezi aniontem a amidem hraje v\u00FDznamnou roli p\u0159i vazb\u011B a rozpozn\u00E1v\u00E1n\u00ED v p\u0159irozen\u00FDch vazebn\u00FDch centrech protein\u016F. V p\u0159\u00EDpad\u011B um\u011Bl\u00FDch receptor\u016F nen\u00ED ov\u0161em zn\u00E1mo p\u0159\u00EDli\u0161 velk\u00E9 mno\u017Estv\u00ED molekul pro komplexaci aniont\u016F zalo\u017Een\u00FDch na b\u00E1zi amid\u016F. Amidovou skupinu lze pro interakci s anionty vhodn\u00FDm zp\u016Fsobem aktivovat. Vliv substituent\u016F na schopnosti amidov\u00E9 vazby interagovat s anionty byl ji\u017E na na\u0161em pracovi\u0161ti zkoum\u00E1n d\u0159\u00EDve. Byly p\u0159ipraveny a z hlediska komplexa\u010Dn\u00EDch vlastnost\u00ED prozkoum\u00E1ny slou\u010Deniny nesouc\u00ED na obou konc\u00EDch amidov\u00E9 vazby elektronov\u011B chud\u00E9 substituenty nebo naopak substituenty elektronov\u011B bohat\u00E9. Substituenty pak ovliv\u0148uj\u00ED s\u00EDlu vazby aniontu t\u00EDm, \u017Ee zvy\u0161uj\u00ED nebo naopak sni\u017Euj\u00ED elektronovou hustotu. Jak\u00FDm zp\u016Fsobem je silou t\u00E9to vazby ovlivn\u011Bno chir\u00E1ln\u00ED rozpozn\u00E1v\u00E1n\u00ED dosud nen\u00ED zn\u00E1mo. Podobn\u00FDm typem receptoru jsou mo\u010Doviny a thiomo\u010Doviny, kter\u00E9 mohou vytvo\u0159it dv\u011B vod\u00EDkov\u00E9 vazby, a proto v\u00E1\u017E\u00ED zejm\u00E9na takov\u00E9 anionty jako jsou karboxyl\u00E1ty, sulf\u00E1ty, fosf\u00E1ty, apod. Postup prac\u00ED"@cs . . . . "1200"^^ . "750"^^ . . . .