. "5607"^^ . "Pochopen\u00ED evoluce a epidemiologie RNA vir\u016F u jejich p\u0159\u00EDrodn\u00EDch hostitel\u016F e nezbytn\u00FDm p\u0159edpokladem pro p\u0159edv\u00EDd\u00E1n\u00ED v\u00FDskytu nemoc\u00ED a jejich \u00FAsp\u011B\u0161nou regulaci. Arenaviry a hantaviry jsou RNA viry (nej\u010Dast\u011Bji u hlodavc\u016F), kter\u00E9 zp\u016Fsobuj\u00ED hemorrhagickou hore\u010Dku a neurologick\u00E9 poruchy u \u010Dlov\u011Bka. Jsou intenzivn\u011B studov\u00E1ny v Evrop\u011B a Americe, nicm\u00E9n\u011B velmi m\u00E1lo \u00FAdaj\u016F je zn\u00E1mo z Afriky. Recentn\u00ED objevy nov\u00FDch vir\u016F v\u0161ak dokl\u00E1daj\u00ED, \u017Ee ob\u011B tyto skupiny jsou v Africe vysoce diversifikov\u00E1ny. Na z\u00E1klad\u011B dosavadn\u00EDch znalost\u00ED se p\u0159edpokl\u00E1dala velmi dlouh\u00E1 koevolu\u010Dn\u00ED historie virus-hostitel. Tato hypot\u00E9za v\u0161ak nebyla nikdy testov\u00E1na u africk\u00FDch arenavir\u016F a recentn\u00ED studie na hantavirech sp\u00ED\u0161e dokl\u00E1d\u00E1 mo\u017Enost zm\u011Bny hostitel\u016F v z\u00E1vislosti na geografick\u00E9 vzd\u00E1lenosti a lok\u00E1ln\u00EDch adaptac\u00EDch, co\u017E m\u016F\u017Ee m\u00EDt dalekos\u00E1hl\u00E9 d\u016Fsledky pro virov\u00E9 n\u00E1kazy a boj s nimi. N\u00E1\u0161 mezin\u00E1rodn\u00ED projektov\u00FD t\u00FDm slo\u017Een\u00FD z odborn\u00EDk\u016F na ekologii hlodavc\u016F, evolu\u010Dn\u00ED biologii a virologii, m\u00E1 za c\u00EDl vyplnit mezeru v poznatc\u00EDch o biodiverzit\u011B, biogeografii a evolu\u010Dn\u00ED historii africk\u00FDch arenavir\u016F a hantavir\u016F ve vztahu k jejich hostitel\u016Fm."@cs . "0"^^ . . . . "Biogeography and evolutionary history of two RNA viruses in Africa"@en . "1"^^ . "Understanding the evolution and epidemiology of RNA viruses in their natural hosts is essential for disease emergence prediction and control. Arenaviruses and hantaviruses are (mostly rodent-borne) RNA viruses causing hemorrhagic fevers and neurological disorders in humans. They are well studied in Europe and the Americas but understudied in Africa. However recent discoveries of new viruses suggest they are highly diverse in Africa. Based on previous data, it has been assumed that both groups of viruses have had long co-evolutionary histories with their hosts. However, this has not been adequately tested for African arenaviruses, and a recent study of hantaviruses instead suggests a very short co-history of preferential host switching, which has massive implications forviral emergence and control. Our project team, specialists in rodent ecology, evolution and virology, intends to fill the gap in scientific knowledge of these viruses in Africa by investigating their biodiversity, biogeography and evolutionary history in relation to their hosts."@en . "5607"^^ . . . "hantavirus; arenavirus; Africa; co-evolution; rodents; emerging diseases"@en . "1"^^ . . "Biogeografie a evolu\u010Dn\u00ED historie dvou RNA vir\u016F v Africe"@cs . . "0"^^ . "2011-01-01+01:00"^^ . "2013-12-31+01:00"^^ . . . "1"^^ . . .