. . . "3996"^^ . "2010-12-31+01:00"^^ . "2008-01-01+01:00"^^ . "1"^^ . . . . "developmental biology; 4D reconstructions; physiological aspects of embryogenesis; orofacial region"@en . "1"^^ . "Current research in molecular stomatology deals not only with odontogenesis but also with development of teeth in context of related structures such as the periodontal and interdental tissues, necessary for anchoring the teeth in the jaws. Interactions during development and differentiation of cell populations in these regions have not been properly\u00A0investigated so far and there are missing data to molecular mechanisms of formation of spatially related structures: teeth-periodontium-interdental bone.Application of common procedures (immunohistochemistry, histology etc) will be combined with novel techniques (laser capture microdissection, 4D movie analysis) to reconstruct morphogenetic events (such as proliferation and apoptosis) and to localize candidate signalling molecules in dental and\u00A0 interdental regions. International cooperation and sharing the expertize in the field of morphogenetic mechanisms (Czech Republic) and computer aided reconstruction of embryonic development\u00A0will"@en . "3996"^^ . . . . "V\u00FDzkum pro aplikace v oblasti molekul\u00E1rn\u00ED stomatologie se aktu\u00E1ln\u011B zam\u011B\u0159uje nejenom na samotnou odontogenezi, ale tak\u00E9 na studium morfogeneze zub\u016F v\u00A0kontextu dal\u0161\u00EDch struktur kraniofaci\u00E1ln\u00ED oblasti, zejm\u00E9na periodont\u00E1ln\u00ED a interdent\u00E1ln\u00ED tk\u00E1n\u011B, kter\u00E9 jsounezbytn\u00E9 pro spr\u00E1vn\u00E9 za\u010Dlen\u011Bn\u00ED zub\u016F do \u010Delisti. Interakce p\u0159i v\u00FDvoji a diferenciaci bun\u011B\u010Dn\u00FDch populac\u00ED v t\u011Bchto oblastech nebyly dosud p\u0159ehledn\u011B zpracov\u00E1ny a nejsou dostupn\u00E1 data o molekul\u00E1rn\u00EDch mechanismech koordinuj\u00EDc\u00EDch interakce p\u0159i formov\u00E1n\u00ED prostorov\u011B souvisej\u00EDc\u00EDch struktur: zub\u016F-periodontu a interdent\u00E1ln\u00ED kosti.Aplikace b\u011B\u017En\u00FDch metod (imunohistochemie, histologie atp.) bude kombinov\u00E1na se zcela nov\u00FDmi postupy jako laserov\u00E1 mikrodisekce a video-4D po\u010D\u00EDta\u010Dov\u00E9 rekonstrukce morfogenetick\u00FDch ud\u00E1lost\u00ED (jako proliferace a apopt\u00F3za) a lokalizace kandid\u00E1tn\u00EDch sign\u00E1ln\u00EDch molekul v\u00A0dent\u00E1ln\u00ED a interdent\u00E1ln\u00ED oblasti.Mezin\u00E1rodn\u00ED spolupr\u00E1ce a sd\u00EDlen\u00ED expertn\u00EDch zku\u0161enost\u00ED v oblasti morfogenetick\u00FDch mechanism\u016F (\u010Cesk\u00E1 republika) a po\u010D\u00EDta\u010Dov\u00FDch"@cs . . "Interactions of tooth, periodontium, and interdental bone development"@en . "0"^^ . "16"^^ . . . "Interakce b\u011Bhem v\u00FDvoje zub\u016F, periodontu a interdent\u00E1ln\u00ED kosti"@cs . "16"^^ .