"Rychl\u00FD rozvoj produkce nanomateri\u00E1l\u016F a jejich pou\u017Eit\u00ED v \u0159ad\u011B pr\u016Fmyslov\u00FDch odv\u011Btv\u00ED s sebou nesou zv\u00FD\u0161enou pot\u0159ebu hlub\u0161\u00EDho porozumn\u011Bn\u00ED mechanism\u016Fm jejich interakce s \u017Eiv\u00FDmi organismy. Tato pot\u0159eba je p\u0159edev\u0161\u00EDm d\u00E1na unik\u00E1tn\u00EDmi vlastnostmi nano\u010D\u00E1stic plynouc\u00EDmi z jejich rozm\u011Br\u016F a t\u00EDm schopnost\u00ED pronikat v organismu do tk\u00E1n\u00ED i bun\u011Bk. Nano\u010D\u00E1stice vznikaj\u00ED t\u00E9\u017E v d\u016Fsledku antropogenn\u00ED \u010Dinnosti (pr\u016Fmysl, doprava, lok\u00E1ln\u00ED topeni\u0161t\u011B). Navrhovan\u00E9 interdisciplin\u00E1rn\u00ED centrum z\u00E1kladn\u00EDho v\u00FDzkumu toxicity nano\u010D\u00E1stic bude sdru\u017Eovat pracovi\u0161t\u011B schopn\u00E1 prov\u00E1d\u011Bt komplexn\u00ED studie mechanism\u016F toxicity pr\u016Fmyslov\u011B d\u016Fle\u017Eit\u00FDch a hojn\u011B roz\u0161\u00ED\u0159en\u00FDch nanomateri\u00E1l\u016F a tak\u00E9 antropogenn\u011B produkovan\u00FDch \u010D\u00E1stic v \u017Eivotn\u00EDm prost\u0159ed\u00ED, se zvl\u00E1\u0161tn\u00EDm z\u0159etelem na oblasti se siln\u011B zne\u010Di\u0161t\u011Bn\u00FDm ovzdu\u0161\u00EDm v \u010CR. Studie budou prov\u00E1d\u011Bny na dob\u0159e charakterizovan\u00FDch nano\u010D\u00E1stic\u00EDch (v\u010Detn\u011B monitorov\u00E1n\u00ED b\u011Bhem experiment\u00E1ln\u00EDch expozic) tak, aby z\u00EDskan\u00E9 v\u00FDsledky v oblasti biologick\u00E9ho p\u016Fsoben\u00ED a toxicity t\u011Bchto \u010D\u00E1stic byly kvalitn\u00ED a porovnateln\u00E9 a mohly tak slou\u017Eit pro v\u00FDvoj metod studia toxicity nano\u010D\u00E1stic."@cs . "The rapid expansion of nanomaterials production and their use in many products create a need for understanding the mechanisms of nanomaterial interactions with living systems. This need is above all given by unique properties of nanoparticles related to their dimensions and by their ability to penetrate into various tissues and cells in organism. Nanoparticles are also formed unintentionally as a result of the anthropogenic activities (industry, traffic, local heating). The proposed interdisciplinary centre of basic research will integrate laboratories capable to perform complex studies on mechanism of the toxicity of important and widely used engineered nanoparticles, as well as anthropogenic nanoparticles in the environment with a special attention paid to heavily polluted areas of the Czech Republic. The studies will be performed on thoroughly characterized nanoparticles to obtain valid and comparable results on biological action and toxicity of nanoparticles. Such results may serve as a basis for the development of methods to study the toxicity of nanoparticles."@en . "1"^^ . "nanoparticles; airborne nanoparticles; inhalation toxicity; in vitro mechanistic studies; global gene ex"@en . . . . "2012-01-01+01:00"^^ . . "2018-12-31+01:00"^^ . . . . "13"^^ . . . "13"^^ . . "0"^^ . . "Centrum studi\u00ED toxick\u00FDch vlastnost\u00ED nano\u010D\u00E1stic"@cs . "5"^^ . . "Centre for studies on toxicity of nanoparticles"@en . "80320"^^ . "80320"^^ .