. . "The work will be devoted to the preparation and study of complex magnetic nanoparticles with precisely controlled properties, enhanced chemical stability and biocompatible organic corona for biological and biomedical applications, particularly for MRI and magnetically induced hyperthermia. The reliable control of the magnetic properties will be accomplished by monodisperse magnetic cores of various ferrites and La1-xSrxMnO3 manganite with tunable composition and size. These magnetic cores, exhibiting self-controlled heating in AC magnetic field and exceptionally high spin-spin relaxivity, will be coated by the primary silica layer. After formation of highly stable interface the PEG chains will be attached covalently. The extensive characterizations and detailed magnetic measurements will be carried out comparing the results also with the data obtained for polydisperse samples. The magnetic heating and relaxometric studies of the monodisperse nanoparticles will enable the explanation of the heating mechanism and better insight into the spin-spin relaxivity."@en . "1"^^ . . . "1"^^ . . "1"^^ . "2014-12-31+01:00"^^ . . . . . "9640"^^ . . "Complex magnetic nanoparticles with monodisperse oxide cores and stable organic corona for biological research and biomedical applications"@en . . "0"^^ . "9640"^^ . "2011-01-01+01:00"^^ . "Zam\u00FD\u0161len\u00FD projekt je v\u011Bnov\u00E1n p\u0159\u00EDprav\u011B a studiu komplexn\u00EDch magnetick\u00FDch nano\u010D\u00E1stic s p\u0159esn\u011B \u0159\u00EDzen\u00FDmi vlastnostmi, zv\u00FD\u0161enou chemickou stabilitou a biokompatibiln\u00ED organickou kor\u00F3nou, kter\u00E9 jsou ur\u010Den\u00E9 pro biologick\u00E9 a biomedicin\u00E1ln\u00ED aplikace, zejm\u00E9na pro MRI a magneticky indukovanou hypertermii. Spolehliv\u00E9 \u0159\u00EDzen\u00ED magnetick\u00FDch vlastnost\u00ED bude zaji\u0161t\u011Bno monodisperzn\u00EDmi magnetick\u00FDmi j\u00E1dry r\u016Fzn\u00FDch ferit\u016F a manganitu La1-xSrxMnO3 s laditeln\u00FDm slo\u017Een\u00EDm a velikost\u00ED. Tato magnetick\u00E1 j\u00E1dra, vykazuj\u00EDc\u00ED autoregulaci topn\u00E9ho v\u00FDkonu ve st\u0159\u00EDdav\u00E9m poli a mimo\u0159\u00E1dn\u011B vysokou spin-spinovou relaxivitu, budou\u00A0pokryty\u00A0prim\u00E1rn\u00ED k\u0159emi\u010Ditou vrstvou. Po vytvo\u0159en\u00ED vysoce stabiln\u00EDho rozhran\u00ED se kovalentn\u011B nav\u00E1\u017E\u00ED PEGylov\u00E9 \u0159et\u011Bzce za vzniku sekund\u00E1rn\u00ED organick\u00E9 vrstvy. Sou\u010Dasn\u011B se budou prov\u00E1d\u011Bt rozs\u00E1hl\u00E9 charakterizace a podrobn\u00E1 magnetick\u00E1 m\u011B\u0159en\u00ED, p\u0159i\u010Dem\u017E v\u00FDsledky se tak\u00E9 budou srovn\u00E1vat s polydisperzn\u00EDmi vzorky. Relaxometrick\u00E9 studie a studie magnetick\u00E9ho zah\u0159\u00EDv\u00E1n\u00ED monodispersn\u00EDch \u010D\u00E1stic umo\u017En\u00ED vysv\u011Btlit mechanismus magnetick\u00E9ho topen\u00ED a l\u00E9pe postihnout vysok\u00E9 spin-spinov\u00E9 relaxivity."@cs . "Komplexn\u00ED magnetick\u00E9 nano\u010D\u00E1stice s monodisperzn\u00EDmi oxidov\u00FDmi j\u00E1dry a stabiln\u00EDm organick\u00FDm obalem pro biologick\u00FD v\u00FDzkum a biomedicin\u00E1ln\u00ED aplikace"@cs . . "1"^^ . . "magnetic oxides; core-shell; manganites; ferrites; hydrotermal synthesis; thermal decomposition"@en .