"1"^^ . . . "Toxic compounds activating Ah receptor (AhR) present an important group of environmental polutants, which may have deleterious effects on both animal and human health. Analysis of signaling pathways affected by AhR enables to describe both the mechanisms being responsible for the toxic effects of these compounds and to contribute to understanding of the role of specific signaling modules in physiological and pathological processes. The proposed project will focuse on the analysis of interactions of AhR signaling and the processes controlled by Wnt signaling, which plays a crucial role in development, as well as e.g. in carcinogenesis. We will study interactions of both signaling pathways at the cellular level in regulation of expression of modell target genes, expression and activity of biotransformation enzymes and the factors modulating cell proliferation/cell death in modle liver and colon cells. The project will bring a novel information about the importance of AhR - Wnt interactions in toxic effects of AhR ligands, tumor development and in regulation of liver physiological functions."@en . "Interactions of Wnt and Ah receptor signaling in regulation of functions of liver cells"@en . . "3614"^^ . . "3614"^^ . "2011-12-31+01:00"^^ . . . "Ah receptor; Wnt; beta-katenin; bun\u011B\u010Dn\u00E1 proliferace; apopt\u00F3za; jatern\u00ED bu\u0148ky; karcinogeneze"@en . . . "2"^^ . . . "0"^^ . "Interakce sign\u00E1ln\u00EDch drah Wnt a Ah receptoru v regulaci funkc\u00ED jatern\u00EDch bun\u011Bk"@cs . "2"^^ . "0"^^ . . . "Z\u00E1kladn\u00EDm c\u00EDlem projektu je charakterizace interakc\u00ED sign\u00E1ln\u00EDch drah Ah receptoru a Wnt, kter\u00E1 by mohla hr\u00E1t roli v negativn\u00EDch \u00FA\u010Dinc\u00EDch toxick\u00FDch environment\u00E1ln\u00EDch polutant\u016F. Vz\u00E1jemn\u00E9 interakce t\u011Bchto dvou drah budou studov\u00E1ny p\u0159edev\u0161\u00EDm s vyu\u017Eit\u00EDm definovan\u00FDch bun\u011B\u010Dn\u00FDch model\u016F in vitro."@cs . "2009-01-01+01:00"^^ .