. . "1"^^ . "0"^^ . "The proposed project is an integral part of oncogene research, which is the central point of current molecular biology not only for its direct use in the clinical research but also for its immense theoretical consequences. In fact, the vast majority of past studies of v-src oncogene, which is a prototype of non-receptor protein tyrosine kinases, have focussed on the biochemical mechanisms underlying cell tranformation. However, the role of v-src in oncogenesis does not end with the oncogene-induced changes that underlie cell transformation, but includes also the oncogene-induced changens that render tumor cell immunogenic to the host. Important aim of our project is therefore the characterisation of genetic requirements for host (immune) defence to srconcogenesis. This is necessary theoretical basis for development of succesful strategies for immunotherapy of cancer, because of the high specificity of antitumor responce, in which the polymorphism of MHC plays a decisive role. For this purposes we tak"@en . "7"^^ . "7"^^ . . "678"^^ . "678"^^ . . "MHC congenic lines of chickens - a model system for both immune and non-immune mechanisms of the regulation of tumor growth"@en . . "P\u0159edlo\u017Een\u00FD projekt je sou\u010D\u00E1st\u00ED v\u00FDzkumu onkogen\u016F, kter\u00FD je v centru pozornosti sou\u010Dasn\u00E9 molekul\u00E1rn\u00ED biologie, nejenom pro sv\u00E9 p\u0159\u00EDm\u00E9 pou\u017Eit\u00ED v klinick\u00E9m v\u00FDzkumu, ale tak\u00E9 pro svoje dalekos\u00E1hl\u00E9 teoretick\u00E9 d\u016Fsledky. V minulosti bylo studium onkogenu v-src, kter\u00FD je prototypem nereceptorov\u00FDch protein tyrosin kin\u00E1z, soust\u0159ed\u011Bno p\u0159ev\u00E1\u017En\u011B na biochemick\u00E9 mechanizmy bun\u011B\u010Dn\u00E9 transformace. Role v-src v onkogenezi v\u0161ak nekon\u010D\u00ED se zm\u011Bnami vedouc\u00EDmi k bun\u011B\u010Dn\u00E9 transformaci, ale zahrnuje tak\u00E9 zm\u011Bny, kter\u00E9 \u010Din\u00ED n\u00E1dorovoubu\u0148ku imunogenn\u00ED pro hostitele. Proto je d\u016Fle\u017Eit\u00FDm c\u00EDlem na\u0161eho projektu charakterizace genetick\u00FDch p\u0159edpoklad\u016F (imunitn\u00ED) obrany hostitele proti onkogenezi zp\u016Fsoben\u00E9 src. To vytv\u00E1\u0159\u00ED nezbytn\u00FD teoretick\u00FD z\u00E1klad pro v\u00FDvoj \u00FAsp\u011B\u0161n\u00FDch strategi\u00ED imunoterapie n\u00E1dor\u016F, vzhledem k vysok\u00E9mu stupni specifi\u010Dnosti protin\u00E1dorov\u00E9 odpov\u011Bdi, p\u0159i kter\u00E9 hraje rozhoduj\u00EDc\u00ED roli polymorfismus MHC. Pro tyto \u00FA\u010Dely vyu\u017E\u00EDv\u00E1me unik\u00E1tn\u00ED soubor kongenn\u00EDch lini\u00ED slepic chovan\u00FDch v na\u0161em \u00FAstavu. V\u00FDsledky z\u00EDskan\u00E9 na na\u0161em modelu ku\u0159et"@cs . "0"^^ . . . . . . . "Linie slepic kongenn\u00ED v MHC - modelov\u00FD syst\u00E9m pro imunn\u00ED a neimunn\u00ED mechanismy regulace n\u00E1dorov\u00E9ho r\u016Fstu"@cs .