"0"^^ . "Role of plant phospholipide - cytoskeleton signaling in aluminum toxicity"@en . . "3395"^^ . "2005-01-01+01:00"^^ . . . "2007-12-31+01:00"^^ . "Aluminium (Al) is highly cytotoxic metal to plants and animals as well and is responsible for significant losses in world crop production. The molecular base of Al toxicity is still far from being understood. Plant cell cytoskeleton appears to be extremely sensitive to Al. Moreover, Al seems to impact phospholipases in plant cells. The important role of phospholipases in regulation of cytoskeletal dynamics in animal organisms is now evident. On the other hand, there are no information about relationship between phospholipid-cytoskeleton signalling and Al toxicity in plant cells. The first part of the project is focused on the study of an effect of Al on the activities of phospholipases and effect of phospholipase inhibitors and /or lipid mediators on cytoskeleton organization in Al-treated and non-treated tobacco cells. In the second part of the project indirect and direct interactions of phospholipases with cytoskeleton in Al-treated and non-treated tobacco cells will be studied."@en . . "1"^^ . . "3395"^^ . "3"^^ . . . "3"^^ . "Hlin\u00EDk (Al) je vysoce toxick\u00FD kov pro rostliny i \u017Eivo\u010Dichy. N\u00E1sledkem jeho toxick\u00E9ho p\u016Fsoben\u00ED je v\u00FDznamn\u00FD pokles produkce zem\u011Bd\u011Blsk\u00FDch plodin na cel\u00E9m sv\u011Bt\u011B. Molekul\u00E1rn\u00ED z\u00E1klad toxicity Al v rostlin\u00E1ch je p\u0159es intenzivn\u00ED v\u00FDzkum st\u00E1le nezn\u00E1m\u00FD. Rostlinn\u00FD cytoskelet je velmi citliv\u00FD na toxick\u00E9 p\u016Fsoben\u00ED Al. Bylo d\u00E1le pops\u00E1no, \u017Ee Al ovliv\u0148uje aktivitu fosfolip\u00E1z v rostlinn\u00FDch bu\u0148k\u00E1ch. V \u017Eivo\u010Di\u0161n\u00FDch bu\u0148k\u00E1ch hraj\u00ED fosfolip\u00E1zy v\u00FDznamnou \u00FAlohu v regulaci dynamiky cytoskeletu. Informace o roli signalizace mezi fosfolip\u00E1zami a cytoskeletem b\u011Bhem p\u016Fsoben\u00ED Al v rostlinn\u00FDch bu\u0148k\u00E1ch v\u0161ak chyb\u00ED. Prvn\u00ED \u010D\u00E1st projektu bude zam\u011B\u0159ena na v\u00FDzkum vlivu Al na aktivity fosfolip\u00E1z a vliv jejich inhibitor\u016F a lipidov\u00FDch medi\u00E1tor\u016F na organizaci cytoskeletu v tab\u00E1kov\u00FDch bu\u0148k\u00E1ch. Druh\u00E1 \u010D\u00E1st projektu se bude zab\u00FDvat nep\u0159\u00EDm\u00FDmi a p\u0159\u00EDm\u00FDmi interakcemi fosfolip\u00E1z s cytoskeletem a rol\u00ED t\u011Bchto interakc\u00ED b\u011Bhem toxick\u00E9hu p\u016Fsoben\u00ED Al."@cs . "2"^^ . . . . "\u00DAloha rostlinn\u00E9ho fosfolipidov\u00E9ho-cytoskelet\u00E1ln\u00EDho sign\u00E1ln\u00EDho syst\u00E9mu b\u011Bhem toxick\u00E9ho p\u016Fsoben\u00ED hlin\u00EDku"@cs . "Aluminum; phospholipase"@en . . .