"Peptidy z intrachin\u00E1rn\u00ED oblasti insulinu, IGF I a IGF II. Sythesa, fyzik\u00E1ln\u011B chemick\u00E9 a biologick\u00E9 vlastnosti"@cs . . "0"^^ . . "718"^^ . . . "Peptides from the Intrachinary Regions of Insulin, IGF I, IGF II. Synthesis, Physiochemical and Biological Properties"@en . . "3"^^ . "3"^^ . "2"^^ . . "1"^^ . . . . "718"^^ . ""@en . "Serie nov\u00FDch peptidov\u00FDch analog\u016F, jejich\u017E sekvence bude odvozena od intrachin\u00E1rn\u00EDch oblast\u00ED jednotliv\u00FDch hormon\u016F, insulinu, IGF I a IGF II bude synthetisov\u00E1na metodou na pevn\u00E9 f\u00E1zi. K izolaci a fyzik\u00E1ln\u011B chemick\u00E9 charakteristice budou vyvinuty nov\u00E9 separa\u010Dn\u00ED a detek\u010Dn\u00ED metody (HPLC, CZE, p\u0159\u00EDp. hmotov\u00E1 spektroskopie). Biologick\u00E9 vlastnosti l\u00E1tek budou srovn\u00E1v\u00E1ny s p\u0159irozen\u00FDmi b\u00EDlkovinn\u00FDmi hormony (proinsulin, IGF I a IGF II) v n\u011Bkolika biologick\u00FDch testech. V\u00FDsledky pomohou ur\u010Dit roli uveden\u00E9 oblasti provazbu a vyvol\u00E1n\u00ED efektu. XXX"@cs .