. "V roce 1962 jsme jako prvn\u00ED zjistili tvorbu 7. hydroxylovan\u00FDch deriv\u00E1t\u016F C19- steroid\u016F u \u010Dlov\u011Bka a rozs\u00E1hle jsme jejich biochemii studovali. V r. 1994 zjistil Morfin v Pa\u0159\u00ED\u017Ei, \u017Ee tyto l\u00E1tky jsou \u00FA\u010Dinn\u00FDmi imunostimul\u00E1tory, \u017Ee jsou aktivn\u00EDm principem p\u0159i imunostimula\u010Dn\u00EDm \u00FA\u010Dinku dehydroepiandrosteronu (navr\u017Een\u00E9ho k terapii HIV) a \u017Ee z\u0159ejm\u011B mechanismus jejich \u00FA\u010Dinku m.j. spo\u010D\u00EDv\u00E1 na vyt\u011Bs\u0148ov\u00E1n\u00ED glukokortikoid\u016F z vazby na receptor. Chceme bl\u00ED\u017Ee sledovat antiglukokortikoidn\u00ED p\u016Fsoben\u00ED p\u0159irozen\u00FDch steroid\u016F substituovan\u00FDch v poloze 7, v\u010Detn\u011B skupiny rostlinn\u00FDch hormon\u016F, brassinolid\u016F, jejich\u017E pou\u017Eit\u00ED v agrotechnice by mohlo m\u00EDt ev. vliv na modulaci imunitn\u00EDho stavu n\u011Bkter\u00FDch popula\u010Dn\u00EDch skupin."@cs . . "459"^^ . "0"^^ . . "As early as in 1962 we found for the first time the formation of 7-hydroxy-derivatives of c19-steroids in man. The extensive study of their biochemistry followed. In 1994 Morfin and co-workers }Paris] brought evidence that these compounds are effective immune-stimulating agents and represent the active immune-stimulating metabolites of dehydroepiandrosterone [the latter has even been suggested for treatment of HIV]. They suggested that the mechanism of action of these compounds may consist in displacement of glucocorticoids from their receptors. In this project we would like to follow up further anti-glucocorticoid effects of naturally occurring steroids substituted at position 7, including a series of plant hormones, brassinolides, the use of whichin agriculture could, eventually, influence [by modulation] the immunity state of some population groups."@en . . . . . "2"^^ . "0"^^ . "1"^^ . "Steroid anti-glucocorticoids"@en . . "Antiglukokortikoidn\u011B \u00FA\u010Dinn\u00E9 steroidy"@cs . . "2"^^ . . . "459"^^ .