. "2"^^ . "Projekt je zam\u011B\u0159en na identifikaci gen\u016F k\u00F3duj\u00EDc\u00EDch imunologicky d\u016Fle\u017Eit\u00E9 proteiny, kter\u00E9 jsou pot\u0159ebn\u00E9 pro obranyschopnost krou\u017Ekovc\u016F (Annelida). Hlavn\u00EDm c\u00EDlem navrhovan\u00E9ho projektu je vytvo\u0159en\u00ED cDNA knihovny, kter\u00E1 bude p\u0159ipravena z coelomocyt\u016F krou\u017Ekovc\u016F druhu Eisenia fetida. Tato knihovna bude vyu\u017Eita pro hybridizace se zna\u010Den\u00FDmi sondami, kter\u00FDmi budou hled\u00E1ny a identifikov\u00E1ny geny k\u00F3duj\u00EDc\u00ED obrann\u00E9 proteiny t\u011Bchto \u017Eivo\u010Dich\u016F, nap\u0159. profenoloxid\u00E1za, antimikrobi\u00E1ln\u00ED proteiny, homology gen\u016F pro proteiny Toll/Imd signaliza\u010Dn\u00EDch drah popsan\u00FDch u drosofily. P\u0159\u00EDpadn\u00E9 nalezen\u00E9 cDNA sekvence budou d\u00E1le pou\u017Eity v dal\u0161\u00EDch experimentech, jako je stanoven\u00ED hladiny exprese a m\u00EDst exprese t\u011Bchto identifikovan\u00FDch obrann\u00FDch protein\u016F."@cs . "2"^^ . "0"^^ . "Identifikace imunologicky v\u00FDznamn\u00FDch gen\u016F u annelid"@cs . . "2009-12-31+01:00"^^ . "2006-01-01+01:00"^^ . "invertebrates; Annelida; comparative and development immunology; cDNA library; identification of genes; Toll receptor"@en . "2157"^^ . . . "0"^^ . . "The proposed project will contribute to identification of genes encoding immunologically important proteins, which are necessary for the defence of earthworms (Oligochaeta; Annelida). The main aim of the proposed project is to create the cDNA library prepared from coelomocytes of Eisenia fetida earthworms. We will screen this cDNA library by hybridization with labelled probes and identify whole genes encoding defence proteins, such as prophenoloxidase, antimicrobial proteins, and homologous of genes for proteins of Toll/Imd pathway found in Drosophila. Potential identified cDNA sequences will be selected for further investigation, such as determination of expression level and sites of expression of identified defence proteins."@en . . . "Identification of immunologically important genes in annelids"@en . . . "1"^^ . . "2157"^^ .