"0"^^ . "2"^^ . . . "859"^^ . "Goldblatt hypertension; AT2 angiotenzin II receptors; renin/angiotensin system; blood pressure"@en . "0"^^ . . . "\u00DAloha AT2 receptor\u016F pro angiotenzin II v regulaci krevn\u00EDho tlaku a patogenezi Goldblattovsk\u00E9 hypertenzi"@cs . . . . "280"^^ . "\"The renin-angiotensin system (RAS) plays a key role in the regulation of arterial blood pressure (BP) and development of hypertension. The main peptide of the RAS is angiotensin II (ANG II). Most \"\"classical\"\" biological effects of ANG II are attributed to activation of AT1 receprtors. Recently, evidence has accumulated that activation of AT2 receptors physiologically antagonizes the effects of ANG II caused by AT1 receptor activation. The aim of our study is to determine whether or not AT2 receptors indeed play a physiological role in the BP control and the development of hypertension. For this purpose, the effects of AT2 receptors blockade on the course of Goldblatt hypertension are to be studied. Also studied will be the possible role of AT2 receptors in mediating the interaction of the RAS with the kallikrein-kinin system and nitric oxide in the development of hypertension. For this purpose AT1A receptor and B2 receptor knockout mice, will be used.\""@en . . "\"Renin-angiotenzinov\u00FD syst\u00E9m (RAS) m\u00E1 kl\u00ED\u010Dovou \u00FAlohu v regulaci v\u00FD\u0161e arteri\u00E1ln\u00EDho krevn\u00EDho tlaku (TK) a rozvoji hypertenze. Hlavn\u00EDm peptidem RAS je angiotenzin II (ANG II), kter\u00FD p\u016Fsob\u00ED p\u0159es dva hlavn\u00ED receptory, AT1, a AT2. V\u011Bt\u0161ina \"\"klasick\u00FDch\"\" biologick\u00FDch \u00FA\u010Dink\u016F ANG II je p\u0159ipisov\u00E1na aktivaci AT1 receptor\u016F. V posledn\u00ED dob\u011B p\u0159ib\u00FDv\u00E1 d\u016Fkaz\u016F, \u017Ee aktivace AT2 receptor\u016F fyziologicky antagonizuje \u00FA\u010Dinky ANG II zp\u016Fsoben\u00E9 aktivac\u00ED AT 1 receptory. C\u00EDlem na\u0161\u00ED studie je ov\u011B\u0159it, zda AT2 receptory maj\u00ED skute\u010Dn\u011B v\u00FDznamnou fyziologickou \u00FAlohu v regulaci TK a kompenzaci nep\u0159im\u011B\u0159en\u011B zv\u00FD\u0161en\u00E1 aktivity RAS. K tomuto \u00FA\u010Delu bude studov\u00E1n vliv akutn\u00ED achronick\u00E9 blok\u00E1dy AT2 receptor\u016F na v\u00FD\u0161i TK a pr\u016Fb\u011Bh Goldblatovsk\u00E9 hypertenze. D\u00E1le bude studov\u00E1na mo\u017En\u00E1 \u00FAloha AT2 receptor\u016F v zprost\u0159edkov\u00E1n\u00ED interakce RAS s syst\u00E9mem kallikrein-kininov\u00FDm a oxidem dusnat\u00FDm v regulaci TK a rozvoji hypertenze. K tomuto \u00FA\u010Delu budou pou\u017Eity kmeny AT1A receptor a B2 receptor deficientn\u00ED my\u0161i.\""@cs . . "1"^^ . . "The role of AT2 angiotensin II receptors in blood presure control and in the pathogenesis of two-kidney, one-clip Goldblatt hypertension"@en . . "2"^^ .