"L\u00E9\u010Dba experiment\u00E1ln\u00EDch n\u00E1dor\u016F glykokonjug\u00E1ty s afinitou pro lektinov\u00E9 lymfocyt\u00E1rn\u00ED receptory (zvl\u00E1\u0161t\u011B potkan\u00ED NKR-P1, my\u0161\u00ED NK1.1), prok\u00E1zala mo\u017Enosti imunomodulace protin\u00E1dorov\u00E9 imunity in vivo. Bu\u0148ky schopn\u00E9 specificky v\u00E1zat a zpracov\u00E1vat sacharidov\u00E9 dendrim\u00E9ry exprimuj\u00ED NKR-P1 (p\u0159\u00EDslu\u0161n\u00E9 isoformy) a zahrnuj\u00ED p\u0159edev\u0161\u00EDm NK bu\u0148ky a bu\u0148ky s fenotypem CD11bc+. I kdy\u017E fysiologick\u00E9 ligandy pro lektinov\u00E9 receptory jsou nezn\u00E1m\u00E9 a dendrim\u00E9ry nespou\u0161t\u00ED adekv\u00E1tn\u00ED bun\u011B\u010Dnou signaliza\u010Dn\u00ED odpov\u011B\u010F, je nezbytn\u00E9 funk\u010Dn\u011B studovat spolupr\u00E1ci aktiva\u010Dn\u00EDch receptor\u016F pat\u0159\u00EDc\u00EDch k imunoglobulin\u016Fm (Ig- FcgammaR), a lektin\u016Fm (NKR-P1, Ly49, CD69), zapojen\u00ED adapta\u010Dn\u00EDch a ko-receptorov\u00FDch molekul (NKG2D). V\u00FDzkum sacharidov\u00FDch l\u00E1tek s nov\u011B v\u00E1zan\u00FDmi substituenty je nutno vztahovat k v\u00FDkonn\u00E9 a c\u00EDlov\u00E9 populaci bun\u011Bk. P\u0159i aktivaci a p\u0159\u00EDpadn\u00E9 asociaci individu\u00E1ln\u00EDch receptor\u016F bude v\u011Bnov\u00E1na pozornost CD4+NK1.1+ populaci NKT bun\u011Bk, kter\u00E9 jsou schopny spou\u0161t\u011Bt a regulovat TH1 nebo TH2 imunitn\u00ED odpov\u011Bdi."@cs . "0"^^ . "2009-12-31+01:00"^^ . "4220"^^ . "6"^^ . . "2005-01-01+01:00"^^ . . "6"^^ . . "0"^^ . . . "Treatment of experimental cancers by glycodendrimers (GD) with affinity for the lectin-like lymphocyte receptors (rat NKR-P1, mouse NK1.1) demonstrated immunomodulation of antitumor immunity in vivo. The spectrum of cells which are able to uptake GD include NK and NKR-P1+cells also expressing CD11bc+. Even if the physiological ligands for lectin-like receptors remain elusive and dendrimers do not trigger alone sufficient signaling, it is of great interest to clarify cooperation of activation receptors belonging to immunoglobulins (Ig- FcgammaR) and lectins (NKR-P1, Ly49, CD69), and involment of the other molecules as adaptors and co-receptors (NKG2D) in presence of GD . During cell activation events and eventually association of individual receptors capable to recognize or to be influenced by GD (Ig, lectin-like,others), we will pay attention to the CD4+NK1.1+ subpopulation of NKT cells, which are potent to trigger and to regulate TH1 or TH2 responses."@en . "immune recognition; cell signalisation; anticancer imunity; immunoglobulin and lectin-like receptors of lymphocytes; carbohydrate dendrimers; natural immunity; NK, NKT cells"@en . "Immune recognition and cell signaling in cancer modulation by bylcoconjugates"@en . . "1"^^ . . . . . "4220"^^ . "Imunitn\u00ED rozpozn\u00E1v\u00E1n\u00ED a bun\u011B\u010Dn\u00E1 signalizace p\u0159i n\u00E1dorov\u00E9 imunomodulaci glykokonjug\u00E1ty"@cs . . .