. "1"^^ . "0"^^ . "Tetraplex je biologicky aktivn\u00ED alternativou dvojit\u00E9 \u0161roubovice DNA. Dosavadn\u00ED studie mal\u00E9 \u010D\u00E1sti lidsk\u00E9ho genomu nazna\u010Duj\u00ED, \u017Ee v n\u011Bm existuj\u00ED tis\u00EDce oblast\u00ED n\u00E1chyln\u00FDch ke tvorb\u011B tetraplex\u016F. V tomto projektu navrhujeme prozkoumat vybran\u00E9 soubory fragment\u016F DNA tak, abychom na z\u00E1klad\u011B jejich chov\u00E1n\u00ED mohli formulovat pravidla pro predikci, kter\u00E9 nukleotidov\u00E9 posloupnosti a za jak\u00FDch podm\u00EDnek budou tvo\u0159it monomolekul\u00E1rn\u00ED a bimolekul\u00E1rn\u00ED tetraplexy. Tato pravidla odstran\u00ED existuj\u00EDc\u00ED rozpory v literatu\u0159e a umo\u017En\u00ED l\u00E9pe pochopit z\u00E1konitosti tvorby tetraplex\u016F. T\u011Bchto pravidel vyu\u017Eijeme k nalezen\u00ED m\u00EDst v lidsk\u00E9m genomu n\u00E1chyln\u00FDch ke tvorb\u011B tetraplexu. Z nich n\u011Bkter\u00E9 podrob\u00EDme experiment\u00E1ln\u00EDm test\u016Fm, abychom zjistili, jak pravidla pro predikci tetraplex\u016F vytvo\u0159en\u00E1 v tomto projektu funguj\u00ED."@cs . . . . "10"^^ . . . "Tetraplexy DNA a jejich v\u00FDskyt v lidsk\u00E9m genomu"@cs . "10"^^ . . "DNA; tetraplex; the human genome"@en . "5078"^^ . "Tetraplexes of DNA and Their Occurrence in the Human Genome"@en . "0"^^ . . . . . "Tetraplex is a biologically active alternative of the DNA double helix. Studies of, so far, a small part of the human genome indicate that it contains thousands of sequences prone to tetraplex formation. In this project, we wuggest to examine selected series of DNA fragments and formulate rules according to their behavior for a prediction of nucleotide sequences and the solution conditions leading to monomolecular or bimolecular tetraplex formation. These rules will eliminate discrepancies existing in the literature and result in a better understanding of principles of tetraplex formation. Using these rules we will find nucleotide sequences in the human genome prone to tetraplex formation. Some of the sequences will be subjected to experimental tests to check how the tetraplex prediction rules work."@en . "2524"^^ .