""@en . . "Molecular and Genetic Mechanism of Genomic Imprinting"@en . . . . . . "421"^^ . . "421"^^ . "0"^^ . "Hlavn\u00EDm c\u00EDlem projektu je analyzovat molekul\u00E1rn\u00ED mechanismy genomov\u00E9ho imprintov\u00E1n\u00ED (genomic imprinting). Projekt je zalo\u017Een na dvou vyj\u00EDme\u010Dn\u00FDch modelech z\u00EDskan\u00FDch ned\u00E1vno v na\u0161\u00ED laborato\u0159i, konkr\u00E9tn\u011B prioritn\u00ED n\u00E1lez variace v imprintov\u00E1n\u00ED Tme genu u mezidruhov\u00FDch my\u0161\u00EDch hybrid\u016F a d\u00E1le existence 11 lini\u00ED transgenn\u00EDch my\u0161\u00ED se stejn\u00FDm H-2K transgenem, kter\u00E9 byly p\u0159ipraveny jako spole\u010Dn\u00FD projekt s laborato\u0159\u00ED M.Pla (U93 INSERM, Pa\u0159\u00ED\u017E). Molekul\u00E1rn\u00ED podstata imprintov\u00E1n\u00ED Tme genu bude studov\u00E1na ve spole\u010Dn\u00E9m projektu s D. Barlow (IMP, V\u00EDde\u0148) a s laborato\u0159\u00ED L.M.Silvera (Princeton University). \u010Cist\u00E9 frakce germin\u00E1ln\u00EDch bun\u011Bk pro studium metyla\u010Dn\u00EDho imprintov\u00E1n\u00ED budou p\u0159ipraveny s pomoc\u00ED A.C.Chandley (Western General Hospital, Edinburgh). Dal\u0161\u00ED laborato\u0159e se budou pod\u00EDlet na n\u011Bkter\u00FDch aspektech projektu, p\u0159edev\u0161\u00EDm J. Klein (Tubingen), H.Lehrach (Lond\u00FDn) a J.L.Guenet (Pa\u0159\u00ED\u017E)."@cs . . "Molekul\u00E1rn\u00ED a genetick\u00E9 mechanismy genomov\u00E9ho imprintov\u00E1n\u00ED"@cs . . "1"^^ . "1"^^ . "1"^^ . "1"^^ .