<n0:ComplexDefinition xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:def-definition>A role used to describe the primary detectable alterations of subcellular, cellular, tissue, or organ functions that directly result from alteration of function of a target biological molecule or complex caused by interaction of a therapeutic agent with a target molecule or complex. The domain and range for this role are 'Drug, Food, Chemical or Biomedical Material' and 'Biological Process', respectively.</n0:def-definition><n0:def-source>NCI</n0:def-source></n0:ComplexDefinition>