<n0:ComplexDefinition xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:def-definition>A fusion gene that results from a chromosomal translocation t(12;16)(q13;p11) which fuses the first 5 exons of the FUS gene on the 5' side of exon 5 of the ATF1 gene. This rearrangement is associated with angiomatoid fibrous histiocytoma.</n0:def-definition><n0:def-source>NCI</n0:def-source></n0:ComplexDefinition>
nci:P98
The ATF1 gene is transcribed from centromere to telomere, while the transcription of FUS proceeds in the opposite direction. The formation of FUS/ATF1 is possible only if another genomic aberration, such as an inversion, occurs in addition to the chromosomal translocation. (Atlas of Genetics and Cytogenetics in Oncology and Haematology)