<n0:ComplexDefinition xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:def-definition>A disorder that affects in multiple tissue types or in multiple organ systems, or affects the body as a whole.</n0:def-definition><n0:def-source>NICHD</n0:def-source></n0:ComplexDefinition><n0:ComplexDefinition xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:def-definition>Disease that affects the whole body.</n0:def-definition><n0:def-source>NCI-GLOSS</n0:def-source></n0:ComplexDefinition>
<n0:ComplexDefinition xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:def-definition>A clinical course finding indicating that a disease presents with systemic manifestations.</n0:def-definition><n0:def-source>NCI</n0:def-source></n0:ComplexDefinition>