SPARQL | HTML Microdata document This HTML5 document contains 23 embedded RDF statements represented using HTML+Microdata notation.
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Namespace Prefixes
Prefix IRI n6 http://linked.opendata.cz/resource/mesh/concept/ rdfs http://www.w3.org/2000/01/rdf-schema# rdf http://www.w3.org/1999/02/22-rdf-syntax-ns# n5 http://linked.opendata.cz/ontology/mesh/ owl http://www.w3.org/2002/07/owl# nci http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl# xsdh http://www.w3.org/2001/XMLSchema#
Statements
Subject Item nci:C77882
rdf:type
owl:Class
rdfs:label
Lexibulin
rdfs:subClassOf
nci:C25974
nci:A8
nci:C63923
nci:P106
Organic Chemical
Pharmacologic Substance
nci:P108
Lexibulin
nci:P207
C2703082
nci:P210
917111-44-5
nci:P319
2GTU230HA1
nci:P322
FDA
nci:P329
598799
nci:P330
598799
nci:P350
C24H30N6O2
nci:P366
Tubulin_Inhibitor_CYT997
nci:P90
<n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>CYT997</n0:term-name><n0:term-group>CN</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>
<n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>1-ethyl-3-(2-methoxy-4-(5-methyl-4-(((1s)-1-(pyridin-3-yl)butyl)amino)pyrimidin-2-yl)phenyl)urea</n0:term-name><n0:term-group>SN</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>
<n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>Lexibulin</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>
<n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>LEXIBULIN</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>FDA</n0:term-source><n0:source-code>2GTU230HA1</n0:source-code></n0:ComplexTerm>
<n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>Tubulin Inhibitor CYT997</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>
nci:P97
<n0:ComplexDefinition xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:def-definition>An orally bioavailable small-molecule with tubulin-inhibiting, vascular-disrupting, and potential antineoplastic activities. Lexibulin inhibits tubulin polymerization in tumor blood vessel endothelial cells and tumor cells, blocking the formation of the mitotic spindle and leading to cell cycle arrest at the G2/M phase; this may result in disruption of the tumor vasculature and tumor blood flow, and tumor cell death.</n0:def-definition><n0:def-source>NCI</n0:def-source></n0:ComplexDefinition>
nci:code
C77882
n5:hasConcept
n6:M0539645