<n0:ComplexDefinition xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:def-definition>Human LSP1 wild-type allele is located in the vicinity of 11p15.5 and is approximately 39 kb in length. This allele, which encodes lymphocyte-specific protein 1, may be involved in the regulation of neutrophil motility, adhesion, and transendothelial migration.</n0:def-definition><n0:def-source>NCI</n0:def-source></n0:ComplexDefinition>
nci:P98
The LSP1 genes can undergo alternative splicing, which results in multiple transcript variants encoding different isoforms. A SNP has been identified in the LSP1 gene (rs3817198), which is associated with increases in breast cancer incidence. (Nature 2007; 447:1087-1093)