<n0:ComplexDefinition xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:def-definition>A staff member assigned primary responsibility for fulfilling core responsibilities for a specific study. Manages the protocol development and review process, working closely with the Protocol Chair and the study team to develop the protocol and prepare responses. Coordinates the protocol development and study implementation teams throughout study development and conduct.</n0:def-definition><n0:def-source>NCI</n0:def-source></n0:ComplexDefinition>