HTML Microdata document

This HTML5 document contains 43 embedded RDF statements represented using HTML+Microdata notation.

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Namespace Prefixes

Prefix	IRI
rdfs	http://www.w3.org/2000/01/rdf-schema#
rdf	http://www.w3.org/1999/02/22-rdf-syntax-ns#
owl	http://www.w3.org/2002/07/owl#
nci	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#
xsdh	http://www.w3.org/2001/XMLSchema#

Statements

Subject Item: nci:C45615
rdf:type: owl:Class
rdfs:label: CYP2C9*5 Allele
rdfs:subClassOf: nci:C21597 _:vb655936 _:vb655937 _:vb655938 _:vb655933 _:vb655934 _:vb655935
nci:P100: 601130
nci:P102: NM_000771
nci:P106: Gene or Genome
nci:P108: CYP2C9*5 Allele
nci:P171: 15289788
nci:P207: C1707204
nci:P366: CYP2C9_5_Allele
nci:P90: <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>CYP2C9, D360E</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>CYP2C9*5</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>Cytochrome P450, Family 2, Subfamily C, Polypeptide 9*5 Allele</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>CYP2C9, c.1080C>G</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>CYP2C9*5 Allele</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>
nci:P96: Cytochrome P450 2C9
nci:P97: <n0:ComplexDefinition xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:def-definition>Human CYP2C9*5 allele is located within 10q24 and is approximately 33 kb in length. This allele, a variant form of the CYP2C9 wild-type allele, encodes cytochrome P450 2C9*5 protein. The CYP2C9*5 allele exhibits a clinically-relevant SNP (c.1080C>G) in exon 7 that results in a D360E coding change. This alteration in the cytochrome P450 2C9*5 protein sequence increases the Km of this enzyme for (S)-warfarin, diclofenac, and lauric acid, thereby decreasing clearance of these drugs.</n0:def-definition><n0:def-source>NCI</n0:def-source></n0:ComplexDefinition>
nci:P98: Ethnicity Association: African American
nci:code: C45615

Subject Item: _:vb655933
rdf:type: owl:Restriction
owl:onProperty: nci:R159
owl:someValuesFrom: nci:C45423

Subject Item: _:vb655934
rdf:type: owl:Restriction
owl:onProperty: nci:R155
owl:someValuesFrom: nci:C13596

Subject Item: _:vb655935
rdf:type: owl:Restriction
owl:onProperty: nci:R153
owl:someValuesFrom: nci:C18135

Subject Item: _:vb655936
rdf:type: owl:Restriction
owl:onProperty: nci:R158
owl:someValuesFrom: nci:C26533

Subject Item: _:vb655937
rdf:type: owl:Restriction
owl:onProperty: nci:R153
owl:someValuesFrom: nci:C45651

Subject Item: _:vb655938
rdf:type: owl:Restriction
owl:onProperty: nci:R158
owl:someValuesFrom: nci:C26633