<n0:ComplexDefinition xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:def-definition>Integrin Inhibition involves interference with, or restraint of, the activities of a family of noncovalent heterodimeric transmembrane glycoprotein signal transduction receptors for fibronectin, laminin, and other adhesive extracellular matrix glycoproteins, complement, and other cells. Different alpha and beta complexes vary in ligand-specificity and the intracellular domains interact with cytoskeleton.</n0:def-definition><n0:def-source>NCI</n0:def-source></n0:ComplexDefinition>