<n0:ComplexDefinition xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:def-definition>The Human Pharmacology Study is a clinical study that involves one or more of following activities: assesses tolerance to the agent, defines/describes pharmacokinetics and pharmacodynamics, explores drug metabolism, drugs interactions, and evaluates agent activity. The term usually refers to early clinical stages of drug development.</n0:def-definition><n0:def-source>NCI</n0:def-source></n0:ComplexDefinition>