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Namespace Prefixes

Prefix	IRI
rdfs	http://www.w3.org/2000/01/rdf-schema#
rdf	http://www.w3.org/1999/02/22-rdf-syntax-ns#
owl	http://www.w3.org/2002/07/owl#
nci	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#
xsdh	http://www.w3.org/2001/XMLSchema#

Statements

Subject Item

nci:C38569

rdf:type

owl:Class owl:DeprecatedClass

rdfs:label

Nitric Oxide Synthase 2C

rdfs:subClassOf

nci:C104171

nci:P100

600720

nci:P106

Amino Acid, Peptide, or Protein Enzyme

nci:P108

Nitric Oxide Synthase 2C

nci:P200

Nitric_Oxide_Synthetase

nci:P204

Gene_Product_Plays_Role_In_Biological_Process some Oxidation/Reduction Gene_Product_Has_Biochemical_Function some Oxidoreductase Gene_Product_Encoded_By_Gene some 'NOS2C Gene' Gene_Product_Plays_Role_In_Biological_Process some 'Intercellular Communication Process'

nci:P207

C1518335

nci:P310

Retired_Concept

nci:P366

Nitric_Oxide_Synthase-2C

nci:P90

<n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>NOS Type IIC</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>NOS2C</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>Nitric Oxide Synthase 2C</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>NOSIIC</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>Nitric Oxide Synthase IIC</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>

nci:P93

Q14961

nci:P97

<n0:ComplexDefinition xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:def-definition>Encoded by human NOS2C Gene (NOS Family), calcium/calmodulin stimulated homodimeric Nitric Oxide Synthase 2C binds FAD and FMN cofactors, requires BH4 which may stabilize the dimer, and synthesizes reactive free radical nitric oxide messenger (from L-arginine). NO has antimicrobial and antitumoral activities in macrophages. NOS2C may bind SLC9A3R1. IL12 requires NOS2 to stimulate NK cell cytotoxicity and to activate STAT4 tyrosine-phosphorylation by TYK2 in innate immunity. (NCI)</n0:def-definition><n0:def-source>NCI</n0:def-source></n0:ComplexDefinition>

nci:P98

Wed Sep 26 15:24:34 EDT 2012 - Q14961 has been designated Obsolete and deleted by UniProtKB/Swiss-Prot. The NOS2C gene is a pseudogene. No protein is encoded.

nci:code

C38569