<n0:ComplexDefinition xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:def-definition>Expressed in a variety of cell types by human MLLT4 Gene, 1816-aa 206-kDa AF-6 Protein is a possible signal transduction protein controlled by Ras signaling pathways that is strongly similar to afadin (rat) and contains short stretches rich in proline, charged amino acids, serines, or glutamines, 1 dilute domain, 1 FHA domain, 1 PDZ/DHR domain, and 2 RAS-associating domains. Shared with several vertebrate and invertebrate proteins, the MLLT4 GLGF motif may be involved in signal transduction at special cell-cell junctions. MLLT4 binds directly to ZO-1 and occludin. MLLT4 may bind to actin filaments, linking the actin cytoskeleton to the plasma membrane at cell-to-cell adherens junctions. A common acute leukemia chromosomal translocation t(6;11)(q27;q23) involves fusion of MLLT4 and MLL/HRX that results in production of a rogue activator protein.</n0:def-definition><n0:def-source>NCI</n0:def-source></n0:ComplexDefinition>