Biologically Active SubstanceAmino Acid, Peptide, or Protein
nci:P108
Growth Factor Receptor-Bound Protein 10
nci:P207
C0296936
nci:P366
Growth_Factor_Receptor-Bound_Protein-10
nci:P90
<n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>Growth Factor Receptor-Bound Protein 10</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm><n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>GRB10</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>
nci:P93
Q13322
nci:P97
<n0:ComplexDefinition xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:def-definition>Grb10 belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. It interacts with IGF1R, PDGFRB, and EGFR and binds to the Raf-1 and MEK1 kinases. Its cellular role is still unclear and a positive as well as an inhibitory role in mitogenesis depending on the cell context has been implicated. Grb10 may regulate signaling between plasma membrane receptors and the apoptosis-inducing machinery on the mitochondrial outer membrane. (from LocusLink, J Biol Chem 1999;274:35719-24, and Mol Cell Biol 1999;19:6217-28)</n0:def-definition><n0:def-source>NCI</n0:def-source></n0:ComplexDefinition>