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Namespace Prefixes

Prefix	IRI
n5	http://linked.opendata.cz/resource/mesh/concept/
rdfs	http://www.w3.org/2000/01/rdf-schema#
rdf	http://www.w3.org/1999/02/22-rdf-syntax-ns#
n4	http://linked.opendata.cz/ontology/mesh/
owl	http://www.w3.org/2002/07/owl#
nci	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#
xsdh	http://www.w3.org/2001/XMLSchema#

Statements

Subject Item: nci:C25948
rdf:type: owl:Class
rdfs:label: Cytochrome P450 2C19
owl:equivalentClass: _:vb631773
nci:P100: 124020
nci:P106: Enzyme Amino Acid, Peptide, or Protein
nci:P108: Cytochrome P450 2C19
nci:P207: C0960580
nci:P366: Cytochrome-P450-2C19
nci:P90: <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>(S)- Limonene 7-Monooxygenase</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>(S)- Limonene 6-Monooxygenase</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>EC 1.14.13.80</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>P450-254C</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>(R)- Limonene 6-Monooxygenase</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>Cytochrome P450 2C19</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>Microsomal Monooxygenase</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>CYPIIC17</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>EC 1.14.13.49</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>Cytochrome P450-11A</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>EC 1.14.13.48</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>CYP2C19</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>CYPIIC19</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>Mephenytoin 4-Prime-Hydroxylase</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>Cytochrome P450, Family 2, Subfamily C, Polypeptide 19</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>EC 1.14.13.-</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>Mephenytoin 4-Hydroxylase</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>Cytochrome P450-254C</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>Flavoprotein-Linked Monooxygenase</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>P450-11A</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 19</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>Xenobiotic Monooxygenase</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>Mephenytoin 4'-Hydroxylase</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>
nci:P93: P33261
nci:P97: <n0:ComplexDefinition xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:def-definition>Cytochrome P450 2C19 (490 aa, ~56 kDa) is encoded by the human CYP2C19 gene. This protein is involved in steroid, terpenoid and drug metabolism.</n0:def-definition><n0:def-source>NCI</n0:def-source></n0:ComplexDefinition>
nci:P98: Substrates for cytochrome P450 2C19 include of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine. (UniProt)
nci:code: C25948
n4:hasConcept: n5:M0132976

Subject Item: _:vb631773
rdf:type: owl:Class
owl:intersectionOf: _:vb739109

Subject Item: _:vb664482
rdf:type: owl:Restriction
owl:onProperty: nci:R54
owl:someValuesFrom: nci:C26512

Subject Item: _:vb664483
rdf:type: owl:Restriction
owl:onProperty: nci:R52
owl:someValuesFrom: nci:C16484

Subject Item: _:vb664484
rdf:type: owl:Restriction
owl:onProperty: nci:R45
owl:someValuesFrom: nci:C14225

Subject Item: _:vb664485
rdf:type: owl:Restriction
owl:onProperty: nci:R131
owl:someValuesFrom: nci:C55290

Subject Item: _:vb664486
rdf:type: owl:Restriction
owl:onProperty: nci:R131
owl:someValuesFrom: nci:C91423

Subject Item: _:vb664487
rdf:type: owl:Restriction
owl:onProperty: nci:R131
owl:someValuesFrom: nci:C91598

Subject Item: _:vb664488
rdf:type: owl:Restriction
owl:onProperty: nci:R131
owl:someValuesFrom: nci:C38807

Subject Item: _:vb664489
rdf:type: owl:Restriction
owl:onProperty: nci:R131
owl:someValuesFrom: nci:C91417

Subject Item: _:vb664490
rdf:type: owl:Restriction
owl:onProperty: nci:R131
owl:someValuesFrom: nci:C91422

Subject Item: _:vb664491
rdf:type: owl:Restriction
owl:onProperty: nci:R131
owl:someValuesFrom: nci:C38861

Subject Item: _:vb664492
rdf:type: owl:Restriction
owl:onProperty: nci:R53
owl:someValuesFrom: nci:C26533

Subject Item: _:vb739109
rdf:first: nci:C16484
rdf:rest: _:vb756859

Subject Item: _:vb756859
rdf:first: _:vb664482
rdf:rest: _:vb756860

Subject Item: _:vb756860
rdf:first: _:vb664483
rdf:rest: _:vb756861

Subject Item: _:vb756861
rdf:first: _:vb664484
rdf:rest: _:vb756862

Subject Item: _:vb756862
rdf:first: _:vb664485
rdf:rest: _:vb756863

Subject Item: _:vb756863
rdf:first: _:vb664486
rdf:rest: _:vb756864

Subject Item: _:vb756864
rdf:first: _:vb664487
rdf:rest: _:vb756865

Subject Item: _:vb756865
rdf:first: _:vb664488
rdf:rest: _:vb756866

Subject Item: _:vb756866
rdf:first: _:vb664489
rdf:rest: _:vb756867

Subject Item: _:vb756867
rdf:first: _:vb664490
rdf:rest: _:vb756868

Subject Item: _:vb756868
rdf:first: _:vb664491
rdf:rest: _:vb756869

Subject Item: _:vb756869
rdf:first: _:vb664492
rdf:rest: rdf:nil