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Namespace Prefixes

PrefixIRI
rdfshttp://www.w3.org/2000/01/rdf-schema#
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
owlhttp://www.w3.org/2002/07/owl#
ncihttp://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#
xsdhhttp://www.w3.org/2001/XMLSchema#

Statements

Subject Item
nci:C2472
rdf:type
owl:Class
rdfs:label
LMB-9 Immunotoxin
rdfs:subClassOf
nci:C78532 _:vb686056 _:vb686057 _:vb686058 _:vb686059 _:vb686060
nci:P106
Pharmacologic Substance Amino Acid, Peptide, or Protein
nci:P108
LMB-9 Immunotoxin
nci:P175
691236
nci:P207
C0678023
nci:P303
Advanced colon, esophageal, pancreatic, rectal, and stomach cancer overexpressing Lewis Y antigen
nci:P325
<n0:ComplexDefinition xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:def-definition>A toxic substance linked to an antibody that attaches to tumor cells and kills them.</n0:def-definition><n0:def-source>NCI-GLOSS</n0:def-source></n0:ComplexDefinition>
nci:P329
43018
nci:P330
43018
nci:P366
LMB-9_Immunotoxin
nci:P90
<n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>Immunotoxin LMB-9</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>B3 (dsFv)-PE38</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>LMB-9 Immunotoxin</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>LMB-9</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>LMB-9 immunotoxin</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>NCI-GLOSS</n0:term-source><n0:source-code>CDR0000045968</n0:source-code></n0:ComplexTerm>
nci:P97
<n0:ComplexDefinition xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:def-definition>A recombinant disulfide stabilized anti-Lewis Y IgG immunotoxin containing a 38 KD toxic element derived from the Pseudomonas aeruginosa exotoxin A and a monoclonal antibody fragment, designed to target adenocarcinomas expressing Lewis Y. LMB-9 immunotoxin attaches to tumor cells, facilitating he entry of the exotoxin. The exotoxin moiety induces caspase-mediated apoptosis of tumor cells via a mechanism involving mitochondrial damage; it also catalyzes the transfer of ADP ribose from nicotinamide adenine dinucleotide (NAD) to elongation factor-2 in eukaryotic cells, thereby inactivating elongation factor 2 and inhibiting protein synthesis.</n0:def-definition><n0:def-source>NCI</n0:def-source></n0:ComplexDefinition>
nci:code
C2472
Subject Item
_:vb686056
rdf:type
owl:Restriction
owl:onProperty
nci:R125
owl:someValuesFrom
nci:C17557
Subject Item
_:vb686057
rdf:type
owl:Restriction
owl:onProperty
nci:R125
owl:someValuesFrom
nci:C29860
Subject Item
_:vb686058
rdf:type
owl:Restriction
owl:onProperty
nci:R146
owl:someValuesFrom
nci:C38586
Subject Item
_:vb686059
rdf:type
owl:Restriction
owl:onProperty
nci:R124
owl:someValuesFrom
nci:C41554
Subject Item
_:vb686060
rdf:type
owl:Restriction
owl:onProperty
nci:R124
owl:someValuesFrom
nci:C45524