<n0:ComplexDefinition xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:def-definition>A recombinant form of endogenous Tumor Necrosis Factor alpha manufactured by Genzyme Pharmaceuticals. Tumor necrosis factor-alpha binds to and activates receptors on the cell surface, resulting in modulation of adipocyte metabolism, lysis of tumor cells, and induction of hemorrhagic necrosis of certain transplantable tumors. (NCI04)</n0:def-definition><n0:def-source>NCI</n0:def-source></n0:ComplexDefinition>