<n0:ComplexDefinition xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:def-definition>Any substance that inhibits glutathione transferase, an enzyme that catalyzes the addition of a glutathione moiety to a substrate and is involved in detoxification of endogenous and exogenous compounds. Inhibition of glutathione transferase can increase the half-life and activity of chemotherapeutic agents.</n0:def-definition><n0:def-source>NCI</n0:def-source></n0:ComplexDefinition>