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Namespace Prefixes

PrefixIRI
n6http://linked.opendata.cz/resource/mesh/concept/
rdfshttp://www.w3.org/2000/01/rdf-schema#
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n5http://linked.opendata.cz/ontology/mesh/
owlhttp://www.w3.org/2002/07/owl#
ncihttp://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#
xsdhhttp://www.w3.org/2001/XMLSchema#

Statements

Subject Item
nci:C1842
rdf:type
owl:Class
rdfs:label
BL22 Immunotoxin
rdfs:subClassOf
nci:C78532 _:vb648813 _:vb648814 _:vb648815 nci:C2002 _:vb648816 _:vb648817 _:vb648818
nci:P106
Amino Acid, Peptide, or Protein Pharmacologic Substance
nci:P108
BL22 Immunotoxin
nci:P175
691237
nci:P207
C0796473
nci:P303
Chronic lymphocytic leukemia and CD22 positive lymphoma; hairy cell leukemia; B-cell lymphomas and leukemia; non-Hodgkins lymphoma.
nci:P325
<n0:ComplexDefinition xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:def-definition>A bacterial toxic substance linked to an antibody that attaches to cancer cells and kills them. It belongs to the family of drugs called bacterial immunotoxins.</n0:def-definition><n0:def-source>NCI-GLOSS</n0:def-source></n0:ComplexDefinition>
nci:P329
43322
nci:P330
43322
nci:P366
BL22_Immunotoxin
nci:P90
<n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>RFB4(dsFv)-PE38 Immunotoxin</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>BL22</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>BL22 immunotoxin</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>NCI-GLOSS</n0:term-source><n0:source-code>CDR0000046175</n0:source-code></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>Immunotoxin BL22</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>Anti-CD22 Recombinant Immunotoxin BL22</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>BL22 Immunotoxin [RFB4(dsFv) - PE38</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>BL22 Immunotoxin</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>
nci:P97
<n0:ComplexDefinition xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:def-definition>A recombinant immunotoxin consisting of the Fv portion of the anti-CD22 antibody RFB4 fused to a fragment of Pseudomonas exotoxin-A with potential antineoplastic activity. BL22 immunotoxin binds to CD22, an antigen expressed in B-cell malignancies, thereby delivering its toxin directly to tumor cells. The toxin moiety induces caspase-mediated apoptosis of tumor cells via a mechanism involving mitochondrial damage; it also blocks translational elongation via binding to elongation factor-2 in eukaryotic cells.</n0:def-definition><n0:def-source>NCI</n0:def-source></n0:ComplexDefinition>
nci:code
C1842
n5:hasConcept
n6:M0394107
Subject Item
_:vb648813
rdf:type
owl:Restriction
owl:onProperty
nci:R146
owl:someValuesFrom
nci:C38586
Subject Item
_:vb648814
rdf:type
owl:Restriction
owl:onProperty
nci:R72
owl:someValuesFrom
nci:C12474
Subject Item
_:vb648815
rdf:type
owl:Restriction
owl:onProperty
nci:R124
owl:someValuesFrom
nci:C45524
Subject Item
_:vb648816
rdf:type
owl:Restriction
owl:onProperty
nci:R125
owl:someValuesFrom
nci:C20150
Subject Item
_:vb648817
rdf:type
owl:Restriction
owl:onProperty
nci:R125
owl:someValuesFrom
nci:C29860
Subject Item
_:vb648818
rdf:type
owl:Restriction
owl:onProperty
nci:R124
owl:someValuesFrom
nci:C40474