<n0:ComplexDefinition xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:def-definition>A protein complex that has dual enzymatic activities in DNA synthesis. The enzyme complex both facilitates DNA synthesis by acting as a polymerase and exhibits exonuclease activity that degrades single stranded DNA in the 3' to 5' direction. It is a heterotetramer comprised of the DNA polymerase delta catalytic subunit and 3 DNA polymerase delta accessory subunits.</n0:def-definition><n0:def-source>NCI</n0:def-source></n0:ComplexDefinition>
nci:P98
DNA polymerase delta interaction with the proliferating cell nuclear antigen and the multisubunit replication factor C is essential for leading strand synthesis. (UniProt)