Amino Acid, Peptide, or ProteinNeuroreactive Substance or Biogenic Amine
nci:P108
Chromogranin
nci:P207
C0008586
nci:P325
<n0:ComplexDefinition xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:def-definition>any of a group of acidic polypeptides that are the soluble protein constituents of the secretory granules of the chromaffin cells of the adrenal medulla; they are also widely distributed in endocrine tissues and tumor cells.</n0:def-definition><n0:def-source>CSP2000</n0:def-source></n0:ComplexDefinition>
<n0:ComplexDefinition xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:def-definition>Chromogranins are acidic secretory glycoproteins with a widespread but specific distribution in neuroendocrine tissues. The chromogranin family is heterogenous, consisting of propeptides such as chromogranin-A, chromogranin-B and secretogranin II, which can either elicit an effect themselves, or serve as precursors to a large number of peptides, which are biologically more active.</n0:def-definition><n0:def-source>NCI</n0:def-source></n0:ComplexDefinition>