HTML Microdata document

This HTML5 document contains 62 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

Prefix	IRI
n6	http://linked.opendata.cz/resource/mesh/concept/
rdfs	http://www.w3.org/2000/01/rdf-schema#
rdf	http://www.w3.org/1999/02/22-rdf-syntax-ns#
n5	http://linked.opendata.cz/ontology/mesh/
owl	http://www.w3.org/2002/07/owl#
nci	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#
xsdh	http://www.w3.org/2001/XMLSchema#

Statements

Subject Item: nci:C1464
rdf:type: owl:Class
rdfs:label: Tirapazamine
owl:equivalentClass: _:vb640669
nci:A7: nci:C18434 nci:C449
nci:A8: nci:C63923
nci:P106: Pharmacologic Substance Organic Chemical
nci:P108: Tirapazamine
nci:P175: 130181
nci:P207: C0208407
nci:P210: 27314-97-2
nci:P303: Head and Neck neoplasms; Non-small cell lung cancer; Rhabdomyosarcoma; Small cell lung cancer
nci:P319: 1UD32YR59G
nci:P322: FDA
nci:P325: <n0:ComplexDefinition xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:def-definition>A drug that makes tumor cells more sensitive to radiation therapy.</n0:def-definition><n0:def-source>NCI-GLOSS</n0:def-source></n0:ComplexDefinition>
nci:P329: 42158
nci:P330: 42158
nci:P350: C7H6N4O2
nci:P366: Tirapazamine
nci:P90: <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>Tirazone</n0:term-name><n0:term-group>BR</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>SR 4233</n0:term-name><n0:term-group>CN</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>WIN 59075</n0:term-name><n0:term-group>CN</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>3-Amino-1,2,4-benzotriazine-1,4-dioxide</n0:term-name><n0:term-group>SN</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>TIRAPAZAMINE</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>FDA</n0:term-source><n0:source-code>1UD32YR59G</n0:source-code></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>tirapazamine</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>NCI-GLOSS</n0:term-source><n0:source-code>CDR0000045427</n0:source-code></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>SR4233</n0:term-name><n0:term-group>CN</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>Tirapazamine</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>
nci:P97: <n0:ComplexDefinition xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:def-definition>A benzotriazine di-N-oxide with potential antineoplastic activity. Tirapazamine is selectively activated by multiple reductases to form free radicals in hypoxic cells, thereby inducing single-and double-strand breaks in DNA, base damage, and cell death. This agent also sensitizes hypoxic cells to ionizing radiation and inhibits the repair of radiation-induced DNA strand breaks via inhibition of topoisomerase II. (NCI04)</n0:def-definition><n0:def-source>NCI</n0:def-source></n0:ComplexDefinition>
nci:code: C1464
n5:hasConcept: n6:M0142901

Subject Item: _:vb640669
rdf:type: owl:Class
owl:intersectionOf: _:vb728855

Subject Item: _:vb719860
rdf:type: owl:Restriction
owl:onProperty: nci:R124
owl:someValuesFrom: nci:C40502

Subject Item: _:vb719861
rdf:type: owl:Restriction
owl:onProperty: nci:R125
owl:someValuesFrom: nci:C17557

Subject Item: _:vb719862
rdf:type: owl:Restriction
owl:onProperty: nci:R125
owl:someValuesFrom: nci:C40828

Subject Item: _:vb719863
rdf:type: owl:Restriction
owl:onProperty: nci:R125
owl:someValuesFrom: nci:C25830

Subject Item: _:vb719864
rdf:type: owl:Restriction
owl:onProperty: nci:R125
owl:someValuesFrom: nci:C20150

Subject Item: _:vb728855
rdf:first: nci:C2077
rdf:rest: _:vb735651

Subject Item: _:vb735651
rdf:first: nci:C798
rdf:rest: _:vb793121

Subject Item: _:vb793121
rdf:first: _:vb719860
rdf:rest: _:vb793122

Subject Item: _:vb793122
rdf:first: _:vb719861
rdf:rest: _:vb793123

Subject Item: _:vb793123
rdf:first: _:vb719862
rdf:rest: _:vb793124

Subject Item: _:vb793124
rdf:first: _:vb719863
rdf:rest: _:vb793125

Subject Item: _:vb793125
rdf:first: _:vb719864
rdf:rest: rdf:nil