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Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n11http://linked.opendata.cz/resource/drugbank/drug/DB08996/identifier/chebi/
n6http://linked.opendata.cz/resource/drugbank/drug/DB08996/identifier/wikipedia/
n7http://linked.opendata.cz/resource/drugbank/drug/DB08996/identifier/kegg-compound/
n9http://bio2rdf.org/drugbank:
admshttp://www.w3.org/ns/adms#
n10http://linked.opendata.cz/resource/drugbank/drug/DB08996/identifier/kegg-drug/
n13http://linked.opendata.cz/resource/drugbank/patent/
n12http://linked.opendata.cz/resource/drugbank/drug/DB08996/identifier/drugbank/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
owlhttp://www.w3.org/2002/07/owl#
n3http://linked.opendata.cz/ontology/drugbank/
n4http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#
n15http://linked.opendata.cz/resource/atc/
n14http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB08996
rdf:type
n3:Drug
n3:description
Dimetacrine (Istonil, Istonyl, Linostil, Miroistonil), also known as dimethacrine and acripramine, is a tricyclic antidepressant (TCA) with imipramine-like effects used in Europe and formerly in Japan for the treatment of depression.
n3:generalReferences
# Ishitani R, Saito E, Kitagawa H: The pharmacological studies on dimetacrine. I. Studies on the absorption, distribution and excretion of H3-labeled dimetacrine in the rat. Jpn J Pharmacol. 1970 Sep;20(3):432-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/5312397
n3:group
approved withdrawn
n3:halfLife
Approximately 10 hours. (PMID 5312397)
owl:sameAs
n9:DB08996
dcterms:title
Dimetacrine
adms:identifier
n6:Dimetacrine n7:C12959 n10:D02565 n11:31497 n12:DB08996
n3:patent
n13:3284454
n3:routeOfElimination
Approximately 70% of the doses were excreted in urine and feces within 2 days after treatment. (PMID 5312397)
n3:synonym
Dimetacrine Linostil Miroistonil Istonil 3-(9,9-dimethylacridin-10-yl)-N,N-dimethyl-propan-1-amine Istonyl
n3:toxicity
Dimetacrine may induce severe cardiac toxicity in overdose. This property is unique among the tricyclic antidepressants.
n3:volumeOfDistribution
The highest concentrations of dimetacrine were found at 1 hour after administration but at 3 hours in brain, heart, lung, liver, spleen, kidney, skeletal muscle and adipose tissue of testes. (Carried out in mice, PMID 5312397).
n3:salt
n3:synthesisReference
# http://worldwide.espacenet.com/publicationDetails/biblio?CC=GB&NR=933875&KC=&FT=E&locale=en_EP
n3:IUPAC-Name
n4:271B634B-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B6351-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B6350-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B634D-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B634E-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B634F-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B6349-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B6347-363D-11E5-9242-09173F13E4C5 n4:271B634A-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B6348-363D-11E5-9242-09173F13E4C5
n14:hasATCCode
n15:N06AA18
n3:H-Bond-Acceptor-Count
n4:271B6357-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B6358-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B6352-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B6353-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B6355-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B6354-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B6356-363D-11E5-9242-09173F13E4C5
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
4757-55-5
n3:Bioavailability
n4:271B635C-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B635E-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B635F-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n4:271B6360-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B635B-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B635A-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B635D-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B634C-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B6359-363D-11E5-9242-09173F13E4C5